MS4A3

Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.[5][6]

MS4A3
Identifiers
Aliases	MS4A3, CD20L, HTM4, membrane spanning 4-domains A3
External IDs	OMIM: 606498 MGI: 2158468 HomoloGene: 4472 GeneCards: MS4A3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 60,056,587 bp[1] End 60,071,115 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 11,629,496 bp[2] End 11,640,851 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • perinuclear region of cytoplasm • integral component of membrane • membrane • endomembrane system • cell membrane • specific granule membrane Biological process • regulation of cell cycle • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	932	170813
Ensembl	ENSG00000149516	ENSMUSG00000024681
UniProt	Q96HJ5	Q920C4
RefSeq (mRNA)	NM_001031666 NM_001031809 NM_006138	NM_133246
RefSeq (protein)	NP_001026836 NP_001026979 NP_006129	NP_573509
Location (UCSC)	Chr 11: 60.06 – 60.07 Mb	Chr 19: 11.63 – 11.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.[6]

Interactions

MS4A3 has been shown to interact with CDKN3.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000149516 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024681 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adra CN, Lelias JM, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B (Nov 1994). "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions". Proc Natl Acad Sci U S A. 91 (21): 10178–82. Bibcode:1994PNAS...9110178A. doi:10.1073/pnas.91.21.10178. PMC 44981. PMID 7524084.
6. "Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)".
7. Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. United States. 109 (1): 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Chinami M, Yano Y, Yang X, et al. (2005). "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2". J. Biol. Chem. 280 (17): 17235–42. doi:10.1074/jbc.M413437200. PMID 15671017.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Donato JL, Ko J, Kutok JL, et al. (2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1): 51–8. doi:10.1172/JCI14025. PMC 150822. PMID 11781350.
• Liang Y, Buckley TR, Tu L, et al. (2001). "Structural organization of the human MS4A gene cluster on Chromosome 11q12". Immunogenetics. 53 (5): 357–68. doi:10.1007/s002510100339. PMID 11486273. S2CID 21846867.
• Liang Y, Tedder TF (2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse". Genomics. 72 (2): 119–27. doi:10.1006/geno.2000.6472. PMID 11401424.