Bone morphogenetic protein 3

Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.[5]

BMP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBMP3, BMP-3A, bone morphogenetic protein 3
External IDsOMIM: 112263 MGI: 88179 HomoloGene: 927 GeneCards: BMP3
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q21.21Start81,030,708 bp[1]
End81,057,632 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

651

110075

Ensembl

ENSG00000152785

ENSMUSG00000029335

UniProt

P12645

Q8BHE5

RefSeq (mRNA)

NM_001201

NM_173404
NM_001310677

RefSeq (protein)

NP_001192

NP_001297606
NP_775580

Location (UCSC)Chr 4: 81.03 – 81.06 MbChr 5: 98.85 – 98.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues.

Cancer

BMP3 is hypermethylated in many cases of colorectal cancer (CRC) and hence along with other hypermethylated genes, may be used as a biomarker to detect early stage CRC.[6][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000152785 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029335 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".
  6. Rasmussen SL, Krarup HB, Sunesen KG, Pedersen IS, Madsen PH, Thorlacius-Ussing O (June 2016). "Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review". Colorectal Disease. 18 (6): 549–61. doi:10.1111/codi.13336. PMID 26998585. S2CID 25724654.
  7. Kormi SM, Ardehkhani S, Kerachian MA (November 2017). "New insights into colorectal cancer screening and early detection tests". Colorectal Cancer. 6 (2): 63–68. doi:10.2217/crc-2017-0007.

Further reading


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