CYP11C1
The Cyp11c1 is a fish gene encoding a CYP450 enzyme, which was originally found in Zebrafish (Danio rerio), this enzyme mainly catalyze the formation of cortisol and 11-Ketotestosterone (11-KT).[1] 11-KT is the endogenous androgen in zebrafish.[2] CYP11C is the orthologous to CYP11B, tetrapod's CYP11B1 evolved from CYP11C1 of fish, and CYP11B/11C are the ohonologues to CYP11A, which duplicated during 2R event.[3]
| cytochrome P450, family 11, subfamily c, polypeptide 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | CYP11C1 | ||||||
| Entrez | 791124 | ||||||
| HomoloGene | 128035 | ||||||
| RefSeq (mRNA) | NM_001080204.1 | ||||||
| RefSeq (Prot) | NP_001073673.1 | ||||||
| UniProt | A1XRK1 | ||||||
| Other data | |||||||
| EC number | 1.14.15.4 | ||||||
| Chromosome | 16: 54.46 - 54.48 Mb | ||||||
| |||||||
References
- Zhang Q, Ye D, Wang H, Wang Y, Hu W, Sun Y (June 2020). "Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction". Endocrinology. 161 (6). doi:10.1210/endocr/bqaa048. PMID 32222764.
- Zheng Q, Xiao H, Shi H, Wang T, Sun L, Tao W, et al. (March 2020). "Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone". The Journal of Endocrinology. 244 (3): 487–499. doi:10.1530/JOE-19-0438. PMID 31910154.
- Nelson DR, Goldstone JV, Stegeman JJ (February 2013). "The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368 (1612): 20120474. doi:10.1098/rstb.2012.0474. PMC 3538424. PMID 23297357.
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