Dexamethasone isonicotinate

Dexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause salt and water retention.

Dexamethasone isonicotinate

Names
IUPAC name [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyridine-4-carboxylate
Other names Auxiloson/ Dexamethasone 21-isonicotinate/ Auxilson/ Auxilsone/ Voren/ DEXAMETHASONE ISONICOTINATE/ EINECS 218-866-5/ HE 111/ 2265-64-7/ Pyridine-4-carboxylic acid-(dexamethasone-21') ester/ Pyridin-4-carbonsaeure-(dexamethason-21')-ester [German]/ Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-((4-pyridinylcarbonyl)oxy)-, (11beta,16alpha)/ Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 21-isonicotinate/ Auxison/ Voren [veterinary] (TN)/ UNII-8LGC0BOA71/ AC1L28M0/ C28H32FNO6/ HE-111/ LS-118477/ D07797/ Pyridin-4-carbonsaeure-(dexamethason-21')-ester/ Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-,21-isonicotinate
Identifiers
CAS Number	2265-64-7
3D model (JSmol)	Interactive image
ChemSpider	15881
ECHA InfoCard	100.017.152
PubChem CID	16752
UNII	8LGC0BOA71
CompTox Dashboard (EPA)	DTXSID3057690
InChI InChI=1/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1 Key: BQTXJHAJMDGOFI-NJLPOHDGBY
SMILES O=C(OCC(=O)[C@@]3(O)[C@H](C)C[C@H]2[C@@H]4CCC\1=C\C(=O)\C=C/[C@]/1(C)[C@@]4(F)[C@@H](O)C[C@@]23C)c5ccncc5
Properties
Chemical formula	C28H32FNO6
Molar mass	497.56 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References