Fluocortolone

Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids.

Fluocortolone

Clinical data
Other names	(6S,8S,9R,10S,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
AHFS/Drugs.com	International Drug Names
ATC code	C05AA08 (WHO) D07AC05 (WHO) H02AB03 (WHO)
Identifiers
IUPAC name (1S,2R,8S,10S,11S,13R,14S,15S,17S)-8-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^2,7.0^11,15]heptadeca-3,6-dien-5-one
CAS Number	152-97-6
PubChem CID	9053
DrugBank	DB08971
ChemSpider	8701
UNII	65VXC1MH0J
KEGG	D04218
ChEMBL	ChEMBL251634
CompTox Dashboard (EPA)	DTXSID00861835
ECHA InfoCard	100.005.284
Chemical and physical data
Formula	C22H29FO4
Molar mass	376.468 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C\1\C=C/[C@]4(/C(=C/1)[C@@H](F)C[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@H](C(=O)CO)[C@@H](C[C@@H]23)C)C)C
InChI InChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1 Key:GAKMQHDJQHZUTJ-ULHLPKEOSA-N
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It is similar to fluocortin, but with one less keto group.

See also

• Glucocorticoids
• Corticosteroids

References