Dipraglurant

Dipraglurant (INN) (code name ADX-48621) is a negative allosteric modulator of the mGlu₅ receptor which is under development by Addex Therapeutics for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID).[1][2][3] As of 2014, it is in phase II clinical trials for this indication.[1] Addex Therapeutics is also investigating an extended-release formulation of dipraglurant for the treatment of non-parkinsonian dystonia.[4]

Dipraglurant

Clinical data
ATC code	None
Identifiers
IUPAC name 6-Fluoro-2-[4-(2-pyridinyl)-3-butyn-1-yl]imidazo[1,2-a]pyridine
CAS Number	872363-17-2
PubChem CID	44557636
ChemSpider	25069676
UNII	CV8JZR21A1
CompTox Dashboard (EPA)	DTXSID90236230
Chemical and physical data
Formula	C16H12FN3
Molar mass	265.291 g·mol^−1
3D model (JSmol)	Interactive image
SMILES c1ccnc(c1)C#CCCc2cn3cc(ccc3n2)F
InChI InChI=1S/C16H12FN3/c17-13-8-9-16-19-15(12-20(16)11-13)7-2-1-5-14-6-3-4-10-18-14/h3-4,6,8-12H,2,7H2 Key:LZXMUJCJAWVHPZ-UHFFFAOYSA-N

See also

• Basimglurant
• Fenobam
• Mavoglurant
• Raseglurant

References

1. Martinez A, Gil C (29 July 2013). Emerging Drugs and Targets for Parkinson's Disease. Royal Society of Chemistry. pp. 255–. ISBN 978-1-84973-617-6.
2. Macor JE (2012). Annual Reports in Medicinal Chemistry. Academic Press. pp. 83–. ISBN 978-0-12-396492-2.
3. Fox SH, Brotchie JM (8 October 2014). Levodopa-Induced Dyskinesia in Parkinson's Disease. Springer. pp. 323–. ISBN 978-1-4471-6503-3.
4. "Dipraglurant-ER for dystonia". Addex Therapeutics.

External links

• Dipraglurant-IR for Parkinson's disease levodopa-induced dyskinesia - Addex Therapeutics
• Dipraglurant-ER for dystonia - Addex Therapeutics