HLA-A30

HLA-A30 (A30) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α³⁰ subset of HLA-A α-chains. For A30, the alpha "A" chain are encoded by the HLA-A*30 allele group and the β-chain are encoded by B2M locus.[1] A30 and A*30 are almost synonymous in meaning. A30 is a split antigen of the broad antigen serotype A19. A30 is a sister serotype of A29, A31, A32, A33, and A74.

HLA-A30
(MHC Class I, A cell surface antigen)
HLA-A30
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*30--, β2-microglobulin
Older names	A19
Subtypes
Subtype allele Available structures A30.3 *3001 A30.2 *3002 {{{cNick3}}} *30{{{cAllele3}}} {{{cNick4}}} *30{{{cAllele4}}}
Rare alleles
Subtype allele Available structures A30.4 *3004 {{{rnick2}}} *30{{{rallele2}}} {{{rnick3}}} *30{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

Serotype

A30 recognition of some HLA A*30 gene products[2]

A*30	A30	A19	A31	Sample
allele	%	%	%	size (N)
*3001	89	1	3	3517
*3002	93	1	2	2124
*3004	94	0	0	85

Alleles

HLA A*3001 frequencies

Study population	Freq.  (in %)[3]
India West Coast Parsis	16.0
Mali Bandiagara	14.1
Zambia Lusaka	14.0
South African Natal Zulu	9.5
Jordan Amman	9.3
Pakistan Kalash	9.2
Zimbabwe Harare Shona	9.1
China Beijing	9.0
Kenya	8.4
Sudanese	6.8
Kenya Luo	6.4
India Khandesh Pawra	6.0
Pakistan Pathan	5.6
Cameroon Yaounde	5.5
USA African America	5.0
Kenya Nandi	4.8
Tunisia	4.1
Cameroon Beti	4.0
China Inner Mongolia	3.9
Cameroon Sawa	3.8
China North Han	3.8
Guinea Bissau	3.8
Senegal Niokholo Mandenka	3.8
South Korea (3)	3.5
India North Delhi	3.3
Cameroon Bamileke	3.2
Pakistan Baloch	3.2
Uganda Kampala	3.1
Israel Arab Druse	3.0
China Qinghai Hui	2.7
USA Hispanic	2.6
Brazil	2.5
France South East	2.3
Iran Baloch	2.2
Saudi Arabia Guraiat and …	2.1
USA North American Native…	2.1
Portugal Centre	2.0
Romanian	2.0
Czech Republic	1.9
Taiwan Hakka	1.8
USA Asian	1.8
Brazil Terena	1.7
Georgia Tibilisi Kurds	1.7
USA Caucasians (3)	1.7
China South Han	1.6
Morocco Nador Metalsa Cla…	1.4
Croatia	1.3
Macedonia (4)	1.2
Mexico Mestizos	1.2
India Andhra Pradesh Goll…	1.1
Ireland Northern	1.1
Mexico Chihuahua State Ta…	1.1
Mongolia Buriat	1.1
Pakistan Brahui	1.1
Portugal North	1.1
Thailand	1.1
Allele frequencies presented, only

HLA A*3002 frequencies

Study population	Freq.  (in %)[3]
Zambia Lusaka	23.3
Zimbabwe Harare Shona	14.7
Senegal Niokholo Mandenka	12.4
Cameroon Beti	9.5
Morocco 'Berber' Nador Me…	8.9
South African Natal Zulu	8.5
Cameroon Sawa	7.7
Cameroon Bamileke	7.1
Cameroon Yaounde	6.0
Kenya Luo	5.9
USA African Americans (3)	5.8
Tunisia	5.6
Cameroon Pygmy Baka	5.0
Mexico Guadalajara Mestiz…	4.9
Oman	4.2
Pakistan Baloch	4.0
Uganda Kampala	4.0
Kenya Nandi	3.7
Mali Bandiagara	3.4
Pakistan Brahui	3.4
USA Hispanic	3.4
Guinea Bissau	3.1
USA South Texas Hispanics	3.0
Iran Baloch	2.8
Sudanese	2.8
Brazil	2.5
Portugal Centre	2.0
Saudi Arabia Guraiat and …	1.9
USA North American Native…	1.9
Georgia Tibilisi Kurds	1.7
Belgium	1.6
France South East	1.2
Ireland Northern	1.2
Macedonia	1.2
Pakistan Burusho	1.1
USA Caucasian Bethesda	1.1
Allele frequencies presented, only

Disease association

A*3002 alters Type 1 diabetes risk[4]

References

1. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
2. Allele Query Form IMGT/HLA - European Bioinformatics Institute
3. Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
4. Noble J, Valdes A, Bugawan T, Apple R, Thomson G, Erlich H (2002). "The HLA class I A locus affects susceptibility to type 1 diabetes". Hum Immunol. 63 (8): 657–64. doi:10.1016/S0198-8859(02)00421-4. PMC 4049513. PMID 12121673.