Haplogroup JT (mtDNA)

Haplogroup JT is a human mitochondrial DNA (mtDNA) haplogroup.

Haplogroup JT
Possible time of origin50,300 YBP
Possible place of originSouthwest Asia
AncestorR2'JT
DescendantsJ, T
Defining mutations11251, 15452A, 16126[1]

Origin

Haplogroup JT is descended from the macro-haplogroup R. It is the ancestral clade to the mitochondrial haplogroups J and T.

JT (predominantly J) was found among the ancient Etruscans.[2] The haplogroup has also been found among Iberomaurusian specimens dating from the Epipaleolithic at the Taforalt prehistoric site.[3] One ancient individual carried a haplotype, which correlates with either the JT clade or the haplogroup H subclade H14b1 (1/9; 11%).[4]

Subclades

Tree

This phylogenetic tree of haplogroup JT subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[1] and subsequent published research.

  • R2'JT

Health

Maternally inherited ancient mtDNA variants have clear impact on the presentation of disease in a modern society. Superhaplogroup JT is an example of reduced risk of Parkinson’s disease[5] And mitochondrial and mtDNa alterations continue to be promising disease biomarkers.[6][7]

See also

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6  
L1 L2   L3     L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T

References
  1. van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457. Archived from the original on 4 December 2012. Retrieved 2009-05-20.
  2. http://www.jogg.info/22/Coffman.htm
  3. Bernard Secher; Rosa Fregel; José M Larruga; Vicente M Cabrera; Phillip Endicott; José J Pestano; Ana M González (2014). "The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents". BMC Evolutionary Biology. 14: 109. doi:10.1186/1471-2148-14-109. PMC 4062890. PMID 24885141.
  4. Kefi, Rym; et al. (2016). "On the origin of Iberomaurusians: new data based on ancient mitochondrial DNA and phylogenetic analysis of Afalou and Taforalt populations". Mitochondrial DNA Part A: 1–11. PMID 28034339.
  5. Marom S, Friger M, Mishmar D. MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association. Sci Rep. 2017 Feb 23;7:43449. doi: 10.1038/srep43449. PMID: 28230165; PMCID: PMC5322532.
  6. Rebeca Martín-Jiménez, Olivier Lurette, and Etienne Hebert-Chatelain.DNA and Cell Biology.Aug 2020.1421-1430.http://doi.org/10.1089/dna.2020.5398
  7. Mitochondrion. 2019 May; 46: 307–312.doi: 10.1016/j.mito.2018.07.008
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