IRAK2

Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.[5][6]

IRAK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MOP
Identifiers
Aliases	IRAK2, IRAK-2, interleukin 1 receptor associated kinase 2
External IDs	OMIM: 603304 MGI: 2429603 HomoloGene: 1207 GeneCards: IRAK2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3 Start 10,164,919 bp[1] End 10,243,745 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 E3|6 52.82 cM Start 113,638,467 bp[2] End 113,695,026 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • protein kinase activity • protein homodimerization activity • protein serine/threonine kinase activity • GO:0001948 protein binding • protein heterodimerization activity • ATP binding Cellular component • cytoplasm • cytosol • cell membrane • endosome membrane • cell nucleus Biological process • response to interleukin-1 • negative regulation of sequence-specific DNA binding transcription factor activity • toll-like receptor signaling pathway • protein phosphorylation • JNK cascade • activation of MAPK activity • positive regulation of NF-kappaB transcription factor activity • toll-like receptor 9 signaling pathway • negative regulation of NF-kappaB transcription factor activity • nucleotide-binding oligomerization domain containing signaling pathway • lipopolysaccharide-mediated signaling pathway • signal transduction • regulation of cytokine-mediated signaling pathway • I-kappaB kinase/NF-kappaB signaling • inflammatory response • MyD88-dependent toll-like receptor signaling pathway • GO:0007243 intracellular signal transduction • interleukin-1-mediated signaling pathway • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3656	108960
Ensembl	ENSG00000134070	ENSMUSG00000060477
UniProt	O43187	Q8CFA1
RefSeq (mRNA)	NM_001570	NM_001113553 NM_172161
RefSeq (protein)	NP_001561	NP_001107025 NP_751893
Location (UCSC)	Chr 3: 10.16 – 10.24 Mb	Chr 6: 113.64 – 113.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.[6]

Interactions

IRAK2 has been shown to interact with TRAF6[5][7] and Myd88.[5][7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000134070 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060477 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Muzio M, Ni J, Feng P, Dixit VM (Nov 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. PMID 9374458.
6. "Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2".
7. Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
8. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. Bibcode:2001Natur.413...78F. doi:10.1038/35092578. PMID 11544529. S2CID 4333764.

Further reading

• Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction". Cytokine & Growth Factor Reviews. 9 (3–4): 221–37. doi:10.1016/S1359-6101(98)00018-5. PMID 9918122.
• Maschera B, Ray K, Burns K, Volpe F (Apr 1999). "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB". The Biochemical Journal. 339 ( Pt 2) (2): 227–31. doi:10.1042/0264-6021:3390227. PMC 1220149. PMID 10191251.
• Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
• Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. Bibcode:2001Natur.413...78F. doi:10.1038/35092578. PMID 11544529. S2CID 4333764.
• McDermott EP, O'Neill LA (Mar 2002). "Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1". The Journal of Biological Chemistry. 277 (10): 7808–15. doi:10.1074/jbc.M108133200. PMID 11744690.
• Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (Feb 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". The Journal of Biological Chemistry. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
• Bin LH, Xu LG, Shu HB (Jul 2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
• Kuzmin I, Geil L, Gibson L, Cavinato T, Loukinov D, Lobanenkov V, Lerman MI (Feb 2005). "Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter". Journal of Molecular Biology. 346 (2): 411–22. doi:10.1016/j.jmb.2004.11.066. PMID 15670593.
• Keating SE, Maloney GM, Moran EM, Bowie AG (Nov 2007). "IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination". The Journal of Biological Chemistry. 282 (46): 33435–43. doi:10.1074/jbc.M705266200. PMID 17878161.