KIAA0999

KIAA0999 protein is a protein that in humans is encoded by the SIK3 gene.[5][6][7]

SIK3
Identifiers
Aliases	SIK3, QSK, SIK-3, L19, KIAA0999, SIK family kinase 3, SEMDK
External IDs	OMIM: 614776 MGI: 2446296 HomoloGene: 57023 GeneCards: SIK3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 116,843,402 bp[1] End 117,098,437 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.2 Start 46,012,820 bp[2] End 46,224,194 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • ATP binding • magnesium ion binding • metal ion binding • kinase activity • tau-protein kinase activity Cellular component • cytoplasm • nucleoplasm Biological process • protein phosphorylation • phosphorylation • microtubule cytoskeleton organization • GO:0007243 intracellular signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23387	70661
Ensembl	ENSG00000160584	ENSMUSG00000034135
UniProt	Q9Y2K2	Q6P4S6
RefSeq (mRNA)	NM_001281748 NM_001281749 NM_025164 NM_001366686 NM_001366687	NM_027498
RefSeq (protein)	NP_001268677 NP_001268678 NP_079440 NP_001353615 NP_001353616	NP_081774
Location (UCSC)	Chr 11: 116.84 – 117.1 Mb	Chr 9: 46.01 – 46.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000160584 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034135 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
6. Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
7. "Entrez Gene: KIAA0999 KIAA0999 protein".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (February 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
• Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, Law CL, Wahl A, Carter P (October 2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
• Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR (December 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228.