List of Major League Baseball career losses leaders
In the sport of baseball, a loss is a statistic credited to the pitcher of the losing team who allows the run that gives the opposing team the lead with which the game is won (the go-ahead run). The losing pitcher is the pitcher who allows the go-ahead run to reach base for a lead that the winning team never relinquishes. If a pitcher allows a run which gives the opposing team the lead, his team comes back to lead or tie the game, and then the opposing team regains the lead against a subsequent pitcher, the earlier pitcher does not get the loss.

Cy Young, the all-time leader in games lost.
Cy Young holds the MLB loss record with 316; Pud Galvin is second with 308. Young and Galvin are the only players to earn 300 or more losses.
Key
| Rank | Rank amongst leaders in career games lost. A blank field indicates a tie. |
| Player | Name of player. |
| L | Total career games lost |
| * | Denotes elected to National Baseball Hall of Fame. |
|---|
List
| Rank | Player | L |
|---|---|---|
| 51 | Dennis Martínez | 193 |
| 52 | Mickey Lolich | 191 |
| Rick Reuschel | 191 | |
| Jerry Reuss | 191 | |
| Tom Zachary | 191 | |
| 56 | Al Orth | 189 |
| 57 | Bartolo Colón | 188 |
| Christy Mathewson * | 188 | |
| 59 | Mel Harder | 186 |
| Mike Morgan | 186 | |
| Jack Morris * | 186 | |
| 62 | Earl Whitehill | 185 |
| 63 | Jim Bunning * | 184 |
| Bullet Joe Bush | 184 | |
| Roger Clemens | 184 | |
| 66 | Larry Jackson | 183 |
| Curt Simmons | 183 | |
| 68 | Danny Darwin | 182 |
| Hooks Dauss | 182 | |
| Waite Hoyt * | 182 | |
| 71 | Murry Dickson | 181 |
| Dutch Leonard | 181 | |
| Rick Wise | 181 | |
| 74 | Lee Meadows | 180 |
| Tim Wakefield | 180 | |
| 76 | Pink Hawley | 179 |
| Dolf Luque | 179 | |
| 78 | John Clarkson * | 178 |
| Wilbur Cooper | 178 | |
| 80 | Bill Dinneen | 177 |
| Liván Hernández | 177 | |
| Rube Marquard * | 177 | |
| 83 | Mike Moore | 176 |
| 84 | Red Donahue | 175 |
| 85 | Doyle Alexander | 174 |
| Bob Gibson * | 174 | |
| Tom Hughes | 174 | |
| Jim Perry | 174 | |
| Amos Rusie * | 174 | |
| 90 | Chuck Finley | 173 |
| 91 | Luis Tiant | 172 |
| 92 | Dennis Eckersley * | 171 |
| Larry French | 171 | |
| 94 | Ted Breitenstein | 170 |
| Camilo Pascual | 170 | |
| 96 | Billy Pierce | 169 |
| 97 | Red Ames | 167 |
| Jim Clancy | 167 | |
| Bert Cunningham | 167 | |
| Red Ehret | 167 |
See also
- Baseball statistics
- List of Major League Baseball career wins leaders
- List of Major League Baseball career games started leaders
- List of Major League Baseball career games finished leaders
Sources
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