Mucinous cystadenoma

Mucinous cystadenoma
	Micrograph showing a mucinous cystadenoma of the ovary. H&E stain.
Specialty	Oncology

Mucinous cystadenoma is a benign cystic tumor lined by a mucinous epithelium. It is a type of cystic adenoma (cystadenoma).

Mucinous cystadenomata may arise in a number of locations; however, mucinous cystadenoma at different locations are not generally considered to be related to one another.

Overview

Mucinous cystadenomas may be found in the:

Ovary—ovarian mucinous cystadenoma
Pancreas—pancreatic mucinous cystadenoma
Peritoneum—peritoneal mucinous cystadenoma
Liver—mucinous cystadenoma of the liver[1]
Vermiform appendix—appendiceal mucinous cystadenoma (see cystadenoma)

Ovarian mucinous cystadenoma

Mucinous cystadenomas make up 15–20% of all ovarian tumors. They often become very large and can extend up into the abdomen.

These tumors are usually evaluated using ultrasound, CT scan, or MRI. Findings on imaging studies are nonspecific. These ovarian tumors are usually multi-septated, cystic masses with thin walls. They also contain varying amounts of solid tissue which consists of proliferating stromal tissue, papillae, or malignant tumor cells.

Benign mucinous cystadenomas compose 80% of mucinous ovarian tumors[2] and 20–25% of benign ovarian tumors overall. The peak incidence occurs between 30 and 50 years of age. Benign tumors are bilateral in 5–10% of cases.

Macroscopy

Microscopy

Pancreatic Mucinous Cystadenoma

Pancreatic Mucinous Cystadenoma or Mucinous Cystadenoma of the pancreas (MCN) are a type of mucinous cystic neoplasm of the pancreas.[3] The cure rate is very high in cases on benign cystic lesions, but the case changes if malignant changes ensue.[4] Benign cystadenomas are the most common cystic tumors of the pancreas accounting for 75% of the cases. On an average, mucinous accounts for 40%-50% of cystic tumors, and serous cytadenoma accounts for 30% of it. Mucinous cystadenomas are in the dital pancreas in about 80% of the cases and distal pancreatectomy is needed for resection.[4] In 20% of the cases it is in the head of the pancreas.[3]

Epidemology

Earlier it was believed that MCN occurs exclusively in females who are middle aged. However, occasional occurrence in men have been reported,[3] especially those who are 45 years of age or above.[5]

Primary Retroperitoneal Mucinous Cystadenoma

Cases of primary retroperitoneal mucinous cystadenoma (PRMC) are extremely rare. However, they are observed more frequently in women, with only 4 cases having been found in men.[6] Even though mucinous cystadenoma are common ovarian tumor, what makes PRMC so rare is their retroperitoneal location.

PRMC and benign mucinous cystadenoma of the ovary are microscopically similar. Both are multiloculated cystic neoplasms and are lined by a single layer of tall columnar cells with a clear basal nucleus and cytoplasm. Both of them have identical histochemical and ultrastructural features.[7] Flat to low cuboidal cells, resembling mesothelial cells, in the lining interspersed between columnar cells in the same area is the only histological difference between the two tumors.[7]