Nucleoporin 93

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene.[5][6][7]

NUP93
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IJN, 5IJO
Identifiers
Aliases	NUP93, NIC96, NPHS12, nucleoporin 93kDa, nucleoporin 93
External IDs	OMIM: 614351 MGI: 1919055 HomoloGene: 40971 GeneCards: NUP93
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q13 Start 56,730,118 bp[1] End 56,850,286 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C5 Start 94,214,564 bp[2] End 94,317,227 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0005487 structural constituent of nuclear pore • GO:0001948 protein binding Cellular component • not the membrane • membrane • nuclear periphery • nuclear pore • cell nucleus • nuclear envelope • host cell Biological process • mRNA transport • viral transcription • protein sumoylation • mitotic nuclear envelope disassembly • regulation of cellular response to heat • protein transport • GO:0022415 viral process • GO:0046795 intracellular transport of virus • nuclear pore complex assembly • negative regulation of hydrogen peroxide-induced cell death • tRNA export from nucleus • glomerular visceral epithelial cell migration • nuclear envelope organization • mRNA export from nucleus • renal system development • positive regulation of SMAD protein import into nucleus • SMAD protein signal transduction • glomerular visceral epithelial cell development • regulation of gene silencing by miRNA • poly(A)+ mRNA export from nucleus • regulation of glycolytic process • transport • protein import into nucleus • nucleocytoplasmic transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9688	71805
Ensembl	ENSG00000102900	ENSMUSG00000032939
UniProt	Q8N1F7	Q8BJ71
RefSeq (mRNA)	NM_001242795 NM_001242796 NM_014669	NM_172410 NM_001357266 NM_001357267 NM_001357268
RefSeq (protein)	NP_001229724 NP_001229725 NP_055484	NP_765998 NP_001344195 NP_001344196 NP_001344197
Location (UCSC)	Chr 16: 56.73 – 56.85 Mb	Chr 8: 94.21 – 94.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000102900 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032939 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Grandi P, Dang T, Pane N, Shevchenko A, Mann M, Forbes D, Hurt E (Dec 1997). "Nup93, a Vertebrate Homologue of Yeast Nic96p, Forms a Complex with a Novel 205-kDa Protein and Is Required for Correct Nuclear Pore Assembly". Mol Biol Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
6. Shah S, Tugendreich S, Forbes D (May 1998). "Major Binding Sites for the Nuclear Import Receptor Are the Internal Nucleoporin Nup153 and the Adjacent Nuclear Filament Protein Tpr". J Cell Biol. 141 (1): 31–49. doi:10.1083/jcb.141.1.31. PMC 2132719. PMID 9531546.
7. "Entrez Gene: NUP93 nucleoporin 93kDa".

Further reading

• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Patre M, Tabbert A, Hermann D, et al. (2006). "Caspases target only two architectural components within the core structure of the nuclear pore complex". J. Biol. Chem. 281 (2): 1296–304. doi:10.1074/jbc.M511717200. PMID 16286466.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Nuclear pore complex protein Nup93