Osnat Penn

Osnat Penn (Hebrew: אסנת פן‎) is an Israeli computational biologist. Penn is the third Israeli scientist in three years to win the UNESCO-L’Oréal fellowship, which she received in 2013 for her work on the genetic origins of autism.[1] Penn is currently at the University of Washington in Seattle.[2]

Penn has been responsible for several different computer programs developed at Tel Aviv University in order to aid in biological research.[3] GUIDANCE is a web server used for estimating alignment confidence scores.[4][5] RASER, the RAte Shift EstimatoR, is used to test site-specific evolutionary rate shifts.[6] The Pepitope Server is used to map epitopes using affinity-selected peptides.[7] Her work with autism genetic sequencing which won her the UNESCO-L’Oréal award, worked to identify where there were genetic variations that linked to individuals displaying autism.[8] Her work will also lead to prenatal screening and early diagnosis of autism.[8]

Penn has been published in Cell,[9] Genome Research,[10] Molecular Biology and Evolution,[11] Nucleic Acids Research,[5] Systematic Biology,[12] BMC Evolutionary Biology,[13] PLoS Computational Biology,[14] Bioinformatics,[15] and Proteins.[16]

References
  1. "Israeli Autism Researcher Wins UNESCO Fellowship". Algemeiner. 29 March 2013. Retrieved 26 November 2015.
  2. "Osnat Penn". Eichler Lab. University of Washington. Archived from the original on 16 June 2016. Retrieved 26 November 2015.
  3. "Osnat Penn". Tel Aviv University. Retrieved 26 November 2015.
  4. "The GUIDANCE Server". Tel Aviv University. Retrieved 26 November 2015.
  5. Penn, Osnat; Privman, Eyal; Ashkenazy, Haim; Landan, Giddy; Graur, Dan; Pupko, Tal (2010-07-01). "GUIDANCE: a web server for assessing alignment confidence scores". Nucleic Acids Research. 38 (suppl 2): W23–W28. doi:10.1093/nar/gkq443. ISSN 0305-1048. PMC 2896199. PMID 20497997.
  6. "RASER". Tel Aviv University. Retrieved 26 November 2015.
  7. "The Pepitope Server". Tel Aviv University. Retrieved 26 November 2015.
  8. Kaplan, Michael (31 March 2013). "Autisme : Osnat Zomer-Penn gagne le prix l'OREAL-UNESCO 2013". Israel Valley (in French). Archived from the original on 4 March 2016. Retrieved 26 November 2015.
  9. Bernier, Raphael; Golzio, Christelle; Xiong, Bo; Stessman, Holly A.; Coe, Bradley P.; Penn, Osnat; Witherspoon, Kali; Gerdts, Jennifer; Baker, Carl (2014-07-17). "Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development". Cell. 158 (2): 263–276. doi:10.1016/j.cell.2014.06.017. ISSN 0092-8674. PMC 4136921. PMID 24998929.
  10. Gelfman, Sahar; Burstein, David; Penn, Osnat; Savchenko, Anna; Amit, Maayan; Schwartz, Schraga; Pupko, Tal; Ast, Gil (2012-01-01). "Changes in exon–intron structure during vertebrate evolution affect the splicing pattern of exons". Genome Research. 22 (1): 35–50. doi:10.1101/gr.119834.110. ISSN 1088-9051. PMC 3246205. PMID 21974994.
  11. Privman, Eyal; Penn, Osnat; Pupko, Tal (2012-01-01). "Improving the Performance of Positive Selection Inference by Filtering Unreliable Alignment Regions". Molecular Biology and Evolution. 29 (1): 1–5. doi:10.1093/molbev/msr177. ISSN 0737-4038. PMID 21772063.
  12. Stern, Adi; Mayrose, Itay; Penn, Osnat; Shaul, Shaul; Gophna, Uri; Pupko, Tal (2010-03-01). "An Evolutionary Analysis of Lateral Gene Transfer in Thymidylate Synthase Enzymes". Systematic Biology. 59 (2): 212–225. doi:10.1093/sysbio/syp104. ISSN 1063-5157. PMC 2826268. PMID 20525631.
  13. Blanga-Kanfi, Shani; Miranda, Hector; Penn, Osnat; Pupko, Tal; DeBry, Ronald W.; Huchon, Dorothée (2009-04-02). "Rodent phylogeny revised: analysis of six nuclear genes from all major rodent clades". BMC Evolutionary Biology. 9 (1): 71. doi:10.1186/1471-2148-9-71. ISSN 1471-2148. PMC 2674048. PMID 19341461.
  14. Penn, Osnat; Stern, Adi; Rubinstein, Nimrod D.; Dutheil, Julien; Bacharach, Eran; Galtier, Nicolas; Pupko, Tal (2008-11-07). "Evolutionary Modeling of Rate Shifts Reveals Specificity Determinants in HIV-1 Subtypes". PLoS Comput Biol. 4 (11): e1000214. doi:10.1371/journal.pcbi.1000214. PMC 2566816. PMID 18989394.
  15. Mayrose, Itay; Penn, Osnat; Erez, Elana; Rubinstein, Nimrod D.; Shlomi, Tomer; Freund, Natalia Tarnovitski; Bublil, Erez M.; Ruppin, Eytan; Sharan, Roded (2007-12-01). "Pepitope: epitope mapping from affinity-selected peptides". Bioinformatics. 23 (23): 3244–3246. doi:10.1093/bioinformatics/btm493. ISSN 1367-4803. PMID 17977889.
  16. Bublil, Erez M.; Freund, Natalia Tarnovitski; Mayrose, Itay; Penn, Osnat; Roitburd-Berman, Anna; Rubinstein, Nimrod D.; Pupko, Tal; Gershoni, Jonathan M. (2007-07-01). "Stepwise prediction of conformational discontinuous B-cell epitopes using the Mapitope algorithm". Proteins: Structure, Function, and Bioinformatics. 68 (1): 294–304. CiteSeerX 10.1.1.124.9174. doi:10.1002/prot.21387. ISSN 1097-0134. PMID 17427229.
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