Phosphoadenylylsulfatase
In enzymology, a phosphoadenylylsulfatase (EC 3.6.2.2) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + H2O adenosine 3',5'-bisphosphate + sulfate
| phosphoadenylylsulfatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.6.2.2 | ||||||||
| CAS number | 37289-37-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and H2O, whereas its two products are adenosine 3',5'-bisphosphate and sulfate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in sulfonyl-containing anhydrides. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate sulfohydrolase. Other names in common use include 3-phosphoadenylyl sulfatase, 3-phosphoadenosine 5-phosphosulfate sulfatase, PAPS sulfatase, and 3'-phosphoadenylylsulfate sulfohydrolase. This enzyme participates in sulfur metabolism. It employs one cofactor, manganese.
References
- BALASUBRAMANIAN AS, BACHHAWAT BK (1962). "Enzymic degradation of active sulphate". Biochim. Biophys. Acta. 59 (2): 389–97. doi:10.1016/0006-3002(62)90188-9. PMID 13864264.
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