RAC2

Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[5] It is encoded by the gene RAC2.[6]

RAC2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAC2, EN-7, Gx, HSPC022, p21-Rac2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), Rac family small GTPase 2
External IDsOMIM: 602049 MGI: 97846 HomoloGene: 55699 GeneCards: RAC2
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.1Start37,225,270 bp[1]
End37,244,448 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5880

19354

Ensembl

ENSG00000128340

ENSMUSG00000033220

UniProt

P15153

Q05144

RefSeq (mRNA)

NM_002872

NM_009008

RefSeq (protein)

NP_002863

NP_033034

Location (UCSC)Chr 22: 37.23 – 37.24 MbChr 15: 78.56 – 78.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Members of Rho family of GTPases appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.[6]

Interactions

Rac2 has been shown to interact with ARHGDIA[7][8] and Nitric oxide synthase 2A.[9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000128340 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033220 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ridley AJ (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
  6. "Entrez Gene: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)".
  7. Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (January 1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity". FEBS Lett. 422 (2): 269–73. doi:10.1016/S0014-5793(98)00020-9. PMID 9490022.
  8. Fauré J, Dagher MC (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie. 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. PMID 11368848.
  9. Kuncewicz T, Balakrishnan P, Snuggs MB, Kone BC (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. 281 (2): F326-36. PMID 11457725.

Further reading


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