Phosphoribosyl-ATP diphosphatase
In enzymology, a phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) is an enzyme that catalyzes the chemical reaction
- 1-(5-phosphoribosyl)-ATP + H2O 1-(5-phosphoribosyl)-AMP + diphosphate
| phosphoribosyl-ATP diphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 phosphoribosyl-ATP pyrophosphatase tetramer, Streptomyces coelicolor | |||||||||
| Identifiers | |||||||||
| EC number | 3.6.1.31 | ||||||||
| CAS number | 69553-55-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-ATP and H2O, whereas its two products are 1-(5-phosphoribosyl)-AMP and diphosphate.
This enzyme participates in histidine metabolism. It employs one cofactor, H+.
Nomenclature
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use include phosphoribosyl-ATP pyrophosphatase, and phosphoribosyladenosine triphosphate pyrophosphatase.
References
- Smith DW, Ames BN (July 1965). "Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis". The Journal of Biological Chemistry. 240: 3056–63. PMID 14342333.
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