Poly(adp-ribose) polymerase family member 14

Poly(ADP-ribose) polymerase family member 14 is a protein that, in humans, is encoded by the PARP14 gene. [5]

PARP14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GOY, 3Q6Z, 3Q71, 3SE2, 3SMI, 3SMJ, 3VFQ, 4ABK, 4ABL, 4D86, 4F1L, 4F1Q, 4PY4
Identifiers
Aliases	PARP14, ARTD8, BAL2, PARP-14, pART8, poly(ADP-ribose) polymerase family member 14
External IDs	OMIM: 610028 MGI: 1919489 HomoloGene: 19697 GeneCards: PARP14
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.1 Start 122,680,839 bp[1] End 122,730,840 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 35,832,874 bp[2] End 35,871,544 bp[2]
Gene ontology Molecular function • transferase activity • transferase activity, transferring glycosyl groups • RNA binding • GO:0001948 protein binding • NAD+ binding • NAD+ ADP-ribosyltransferase activity • enzyme binding • protein ADP-ribosylase activity Cellular component • membrane • cell nucleus • cytosol • cytoplasm Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • protein poly-ADP-ribosylation • protein ADP-ribosylation • negative regulation of gene expression • positive regulation of tyrosine phosphorylation of STAT protein • negative regulation of tyrosine phosphorylation of STAT protein • negative regulation of interferon-gamma-mediated signaling pathway • positive regulation of interleukin-4-mediated signaling pathway • immune system process • innate immune system • protein mono-ADP-ribosylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54625	547253
Ensembl	ENSG00000173193	ENSMUSG00000034422
UniProt	Q460N5 Q8N546	Q2EMV9
RefSeq (mRNA)	NM_017554	NM_001039530
RefSeq (protein)	NP_060024 NP_060024.2	NP_001034619
Location (UCSC)	Chr 3: 122.68 – 122.73 Mb	Chr 16: 35.83 – 35.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).

References

1. GRCh38: Ensembl release 89: ENSG00000173193 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034422 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Poly(ADP-ribose) polymerase family member 14". Retrieved 2016-03-02.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.