SCG5

Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene.[5][6][7] The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein, and is required for the production of an active PC2 enzyme.[8][9] It is an intrinsically disordered protein that may also function as a chaperone for other aggregating secretory proteins in addition to proPC2 (Helwig et al 2013). 7B2 has been identified in vertebrates and in invertebrates as low as flatworms (Protein ID: AIZ72728.1) and insects (PMID:10749852). It is also called Sgne1 and Secretogranin V. In C. elegans, it was originally called e7B2 (PMID:972625) and then renamed Seven B Two (gene name sbt-1). There is a Pfam entry for this protein: Secretogranin_V (PF05281).

SCG5
Identifiers
Aliases	SCG5, 7B2, P7B2, SGNE1, SgV, secretogranin V
External IDs	OMIM: 173120 MGI: 98289 HomoloGene: 37722 GeneCards: SCG5
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q13.3 Start 32,641,676 bp[1] End 32,697,098 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E4|2 57.45 cM Start 113,776,362 bp[2] End 113,829,121 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • unfolded protein binding • GO:0048551 enzyme inhibitor activity • GTP binding • GO:0001948 protein binding Cellular component • extracellular region • secretory granule Biological process • regulation of hormone secretion • intracellular protein transport • neuropeptide signaling pathway • peptide hormone processing • GO:0048553 negative regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6447	20394
Ensembl	ENSG00000277614 ENSG00000166922 ENSG00000281931	ENSMUSG00000023236
UniProt	P05408	P12961
RefSeq (mRNA)	NM_001144757 NM_003020	NM_009162
RefSeq (protein)	NP_001138229 NP_003011	NP_033188
Location (UCSC)	Chr 15: 32.64 – 32.7 Mb	Chr 2: 113.78 – 113.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000166922, ENSG00000281931 GRCh38: Ensembl release 89: ENSG00000277614, ENSG00000166922, ENSG00000281931 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023236 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lloyd RV, Jin L (March 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagnostic Molecular Pathology. 3 (1): 38–45. doi:10.1097/00019606-199403010-00007. PMID 8162254.
6. Taupenot L, Harper KL, O'Connor DT (March 2003). "The chromogranin-secretogranin family". The New England Journal of Medicine. 348 (12): 1134–49. doi:10.1056/NEJMra021405. PMID 12646671.
7. Martens GJ (July 1988). "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Letters. 234 (1): 160–4. doi:10.1016/0014-5793(88)81324-3. PMID 3134253.
8. "Entrez Gene: SCG5 secretogranin V (7B2 protein)".
9. Mbikay M, Seidah NG, Chrétien M (July 2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions". The Biochemical Journal. 357 (Pt 2): 329–42. doi:10.1042/0264-6021:3570329. PMC 1221959. PMID 11439082.

Further reading

• Mbikay M, Seidah NG, Chrétien M (July 2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions". The Biochemical Journal. 357 (Pt 2): 329–42. doi:10.1042/0264-6021:3570329. PMC 1221959. PMID 11439082.
• Paquet L, Lazure C, Seidah NG, Chrétien M, Mbikay M (January 1991). "The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man". Biochemical and Biophysical Research Communications. 174 (1): 156–62. doi:10.1016/0006-291X(91)90499-W. PMID 1989596.
• Roebroek AJ, Dehaen MR, van Bokhoven A, Martens GJ, Marÿnen P, van den Berghe H, Van de Ven WJ (1989). "Regional mapping of the human gene encoding the novel pituitary polypeptide 7B2 to chromosome 15q13----q14 by in situ hybridization". Cytogenetics and Cell Genetics. 50 (2–3): 158–60. doi:10.1159/000132749. PMID 2776483.
• Benjannet S, Marcinkiewicz M, Falgueyret JP, Johnson DE, Seidah NG, Chrétien M (August 1988). "Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors". Endocrinology. 123 (2): 874–84. doi:10.1210/endo-123-2-874. PMID 2840270.
• Martens GJ (July 1988). "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Letters. 234 (1): 160–4. doi:10.1016/0014-5793(88)81324-3. PMID 3134253.
• Brayton KA, Aimi J, Qiu H, Yazdanparast R, Ghatei MA, Polak JM, et al. (December 1988). "Cloning, characterization, and sequence of a porcine cDNA encoding a secreted neuronal and endocrine protein". DNA. 7 (10): 713–9. doi:10.1089/dna.1988.7.713. PMID 3234177.
• Marcinkiewicz M, Benjannet S, Falgueyret JP, Seidah NG, Schürch W, Verdy M, et al. (August 1988). "Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma". Endocrinology. 123 (2): 866–73. doi:10.1210/endo-123-2-866. PMID 3293987.
• Marcinkiewicz M, Benjannet S, Cantin M, Seidah NG, Chrétien M (August 1986). "CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles". Brain Research. 380 (2): 349–56. doi:10.1016/0006-8993(86)90233-7. PMID 3530373.
• Seidah NG, Hsi KL, De Serres G, Rochemont J, Hamelin J, Antakly T, et al. (September 1983). "Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus". Archives of Biochemistry and Biophysics. 225 (2): 525–34. doi:10.1016/0003-9861(83)90063-2. PMID 6625600.
• Benjannet S, Savaria D, Chrétien M, Seidah NG (May 1995). "7B2 is a specific intracellular binding protein of the prohormone convertase PC2". Journal of Neurochemistry. 64 (5): 2303–11. doi:10.1046/j.1471-4159.1995.64052303.x. PMID 7722516.
• Braks JA, Martens GJ (July 1994). "7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway". Cell. 78 (2): 263–73. doi:10.1016/0092-8674(94)90296-8. PMID 7913882.
• Braks JA, Broers CA, Danger JM, Martens GJ (February 1996). "Structural organization of the gene encoding the neuroendocrine chaperone 7B2". European Journal of Biochemistry. 236 (1): 60–7. doi:10.1111/j.1432-1033.1996.00060.x. PMID 8617287.
• Bourdeau I, Antonini SR, Lacroix A, Kirschner LS, Matyakhina L, Lorang D, et al. (February 2004). "Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators". Oncogene. 23 (8): 1575–85. doi:10.1038/sj.onc.1207277. PMID 14767469.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Dasgupta I, Sanglas L, Enghild JJ, Lindberg I (September 2012). "The neuroendocrine protein 7B2 is intrinsically disordered". Biochemistry. 51 (38): 7456–64. doi:10.1021/bi300871k. PMC 3457758. PMID 22947085.
• Helwig M, Hoshino A, Berridge C, Lee SN, Lorenzen N, Otzen DE, et al. (January 2013). "The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins". The Journal of Biological Chemistry. 288 (2): 1114–24. doi:10.1074/jbc.M112.417071. PMC 3542996. PMID 23172224.