SYT4

Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene.[5][6]

SYT4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UGK
Identifiers
Aliases	SYT4, HsT1192, synaptotagmin 4
External IDs	OMIM: 600103 MGI: 101759 HomoloGene: 7559 GeneCards: SYT4
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.3 Start 43,267,892 bp[1] End 43,277,535 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B1|18 17.75 cM Start 31,437,808 bp[2] End 31,447,406 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • clathrin binding • phosphatidylserine binding • metal ion binding • GO:0001948 protein binding • SNARE binding • syntaxin-1 binding • syntaxin binding • syntaxin-3 binding • protein homodimerization activity • protein heterodimerization activity • calcium-dependent phospholipid binding Cellular component • integral component of membrane • intracellular membrane-bounded organelle • membrane • synapse • synaptic vesicle membrane • cell junction • perinuclear region of cytoplasm • neuron projection • dense core granule • cytoplasmic vesicle • dendrite • Golgi apparatus • vesicle • axon • cell membrane • synaptic vesicle • integral component of Golgi membrane • integral component of synaptic vesicle membrane • secretory granule membrane • dense core granule membrane • somatodendritic compartment • neuronal cell body • neuron projection terminus • exocytic vesicle • astrocyte projection • microvesicle • glutamatergic synapse • integral component of neuronal dense core vesicle membrane Biological process • cell differentiation • brain development • positive regulation of dendrite extension • negative regulation of vesicle fusion • GO:0010554 neurotransmitter secretion • exocytosis • vesicle fusion • calcium ion-regulated exocytosis of neurotransmitter • memory • positive regulation of glutamate secretion • regulation of dopamine secretion • regulation of endocytosis • regulation of vesicle fusion • negative regulation of catecholamine secretion • positive regulation of calcium ion-dependent exocytosis • negative regulation of neurotransmitter secretion • negative regulation of short-term neuronal synaptic plasticity • vesicle fusion with vesicle • secretory granule maturation • negative regulation of protein secretion • negative regulation of retrograde trans-synaptic signaling by neuropeptide • regulation of calcium ion-dependent exocytosis • negative regulation of calcium ion-dependent exocytosis • trans-synaptic signaling by BDNF, modulating synaptic transmission • vesicle-mediated transport • calcium ion regulated exocytosis • cellular response to calcium ion • regulation of presynaptic dense core granule exocytosis • negative regulation of dense core granule exocytosis • positive regulation of dense core granule exocytosis • negative regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6860	20983
Ensembl	ENSG00000132872	ENSMUSG00000024261
UniProt	Q9H2B2	P40749
RefSeq (mRNA)	NM_020783	NM_009308
RefSeq (protein)	NP_065834	NP_033334
Location (UCSC)	Chr 18: 43.27 – 43.28 Mb	Chr 18: 31.44 – 31.45 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000132872 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024261 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hilbush BS, Morgan JI (Sep 1994). "A third synaptotagmin gene, Syt3, in the mouse". Proc Natl Acad Sci U S A. 91 (17): 8195–9. doi:10.1073/pnas.91.17.8195. PMC 44572. PMID 8058779.
6. "Entrez Gene: SYT4 synaptotagmin IV".

Further reading

• Ullrich B, Li C, Zhang JZ, et al. (1995). "Functional properties of multiple synaptotagmins in brain". Neuron. 13 (6): 1281–91. doi:10.1016/0896-6273(94)90415-4. PMID 7993622. S2CID 23856449.
• Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
• Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Mol. Biol. Cell. 10 (7): 2285–95. doi:10.1091/mbc.10.7.2285. PMC 25443. PMID 10397765.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Ferguson GD, Chen XN, Korenberg JR, Herschman HR (2001). "The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity". J. Biol. Chem. 275 (47): 36920–6. doi:10.1074/jbc.M005801200. PMID 10938284.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9H2B2 (Human Synaptotagmin-4) at the PDBe-KB.