Syntaxin binding protein 2

Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.[5][6]

STXBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CCA
Identifiers
Aliases	STXBP2, FHL5, Hunc18b, MUNC18-2, UNC18-2, UNC18B, pp10122, Syntaxin binding protein 2
External IDs	OMIM: 601717 MGI: 107370 HomoloGene: 55530 GeneCards: STXBP2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 7,636,881 bp[1] End 7,647,873 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 1.92 cM Start 3,630,955 bp[2] End 3,643,644 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • syntaxin-1 binding • syntaxin-3 binding Cellular component • cytolytic granule • tertiary granule • SNARE complex • azurophil granule • specific granule • apical plasma membrane • extracellular exosome • cell membrane • zymogen granule membrane • extracellular region • cytosol • phagocytic vesicle Biological process • protein transport • neutrophil degranulation • vesicle docking involved in exocytosis • regulation of mast cell degranulation • leukocyte mediated cytotoxicity • vesicle-mediated transport • exocytosis • platelet degranulation • transport • cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6813	20911
Ensembl	ENSG00000076944	ENSMUSG00000004626
UniProt	Q15833	Q64324
RefSeq (mRNA)	NM_001127396 NM_001272034 NM_006949	NM_011503 NM_001357168
RefSeq (protein)	NP_001120868 NP_001258963 NP_008880	NP_035633 NP_001344097
Location (UCSC)	Chr 19: 7.64 – 7.65 Mb	Chr 8: 3.63 – 3.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000076944 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004626 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ziegler SF, Mortrud MT, Swartz AR, Baker E, Sutherland GR, Burmeister M, Mulligan JT (Feb 1997). "Molecular characterization of a nonneuronal human UNC18 homolog". Genomics. 37 (1): 19–23. doi:10.1006/geno.1996.0515. PMID 8921365.
6. "Entrez Gene: STXBP2 syntaxin binding protein 2".

Further reading

• Ibaraki K, Horikawa HP, Morita T, et al. (1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732.
• Hata Y, Südhof TC (1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Tellam JT, Macaulay SL, McIntosh S, et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". J. Biol. Chem. 272 (10): 6179–86. doi:10.1074/jbc.272.10.6179. PMID 9045631.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Riento K, Galli T, Jansson S, et al. (1999). "Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells". J. Cell Sci. 111 (17): 2681–8. PMID 9701566.
• Riento K, Kauppi M, Keranen S, Olkkonen VM (2000). "Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells". J. Biol. Chem. 275 (18): 13476–83. doi:10.1074/jbc.275.18.13476. PMID 10788461.
• Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
• Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
• Kauppi M, Wohlfahrt G, Olkkonen VM (2003). "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3". J. Biol. Chem. 277 (46): 43973–9. doi:10.1074/jbc.M208315200. PMID 12198139.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Martin-Verdeaux S, Pombo I, Iannascoli B, et al. (2003). "Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis". J. Cell Sci. 116 (Pt 2): 325–34. doi:10.1242/jcs.00216. PMID 12482918.
• Houng A, Polgar J, Reed GL (2003). "Munc18-syntaxin complexes and exocytosis in human platelets". J. Biol. Chem. 278 (22): 19627–33. doi:10.1074/jbc.M212465200. PMID 12649283.
• Schraw TD, Lemons PP, Dean WL, Whiteheart SW (2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Syntaxin-binding protein 2