Small nuclear ribonucleoprotein polypeptide C

U1 small nuclear ribonucleoprotein C is a protein that in humans is encoded by the SNRPC gene.[3][4][5]

SNRPC
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2VRD, 3CW1, 4PJO
Identifiers
Aliases	SNRPC, U1C, Yhc1, Small nuclear ribonucleoprotein polypeptide C
External IDs	OMIM: 603522 HomoloGene: 136764 GeneCards: SNRPC
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 34,757,505 bp[1] End 34,773,857 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • zinc ion binding • metal ion binding • GO:0001948 protein binding • single-stranded RNA binding • nucleic acid binding • U1 snRNA binding • pre-mRNA 5'-splice site binding • U1 snRNP binding • RNA binding • mRNA binding Cellular component • Cajal body • prespliceosome • U1 snRNP • cell nucleus • commitment complex • nucleoplasm • U2-type prespliceosome Biological process • spliceosomal snRNP assembly • mRNA 5'-splice site recognition • mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6631	n/a
Ensembl	ENSG00000124562	n/a
UniProt	P09234	n/a
RefSeq (mRNA)	NM_003093	n/a
RefSeq (protein)	NP_003084	n/a
Location (UCSC)	Chr 6: 34.76 – 34.77 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Interactions

Small nuclear ribonucleoprotein polypeptide C has been shown to interact with Ewing sarcoma breakpoint region 1.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000124562 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Sillekens PT, Beijer RP, Habets WJ, van Venrooij WJ (September 1988). "Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals". Nucleic Acids Research. 16 (17): 8307–21. doi:10.1093/nar/16.17.8307. PMC 338560. PMID 2971157.
4. Gunnewiek JM, van Aarssen Y, Wassenaar R, Legrain P, van Venrooij WJ, Nelissen RL (December 1995). "Homodimerization of the human U1 snRNP-specific protein C". Nucleic Acids Research. 23 (23): 4864–71. doi:10.1093/nar/23.23.4864. PMC 307476. PMID 8532530.
5. "Entrez Gene: SNRPC small nuclear ribonucleoprotein polypeptide C".
6. Knoop LL, Baker SJ (August 2000). "The splicing factor U1C represses EWS/FLI-mediated transactivation". The Journal of Biological Chemistry. 275 (32): 24865–71. doi:10.1074/jbc.M001661200. PMID 10827180.

Further reading

• Yamamoto K, Miura H, Moroi Y, Yoshinoya S, Goto M, Nishioka K, Miyamoto T (January 1988). "Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide". Journal of Immunology. 140 (1): 311–7. PMID 2961811.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Nelissen RL, Gunnewiek JM, Lambermon MH, Van Venrooij WJ (January 1997). "Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C". Gene. 184 (2): 273–8. doi:10.1016/S0378-1119(96)00612-9. PMID 9031639.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Dumortier H, Klein Gunnewiek J, Roussel JP, van Aarssen Y, Briand JP, van Venrooij WJ, Muller S (December 1998). "At least three linear regions but not the zinc-finger domain of U1C protein are exposed at the surface of the protein in solution and on the human spliceosomal U1 snRNP particle". Nucleic Acids Research. 26 (23): 5486–91. doi:10.1093/nar/26.23.5486. PMC 147990. PMID 9826776.
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (March 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". The Journal of Cell Biology. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
• Knoop LL, Baker SJ (August 2000). "The splicing factor U1C represses EWS/FLI-mediated transactivation". The Journal of Biological Chemistry. 275 (32): 24865–71. doi:10.1074/jbc.M001661200. PMID 10827180.
• Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (March 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
• Förch P, Puig O, Martínez C, Séraphin B, Valcárcel J (December 2002). "The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites". The EMBO Journal. 21 (24): 6882–92. doi:10.1093/emboj/cdf668. PMC 139089. PMID 12486009.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.