Small nuclear ribonucleoprotein polypeptide F

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.[5][6]

SNRPF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR
Identifiers
Aliases	SNRPF, SMF, Sm-F, snRNP-F, Small nuclear ribonucleoprotein polypeptide F
External IDs	OMIM: 603541 MGI: 1917128 HomoloGene: 130366 GeneCards: SNRPF
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.1 Start 95,858,928 bp[1] End 95,903,828 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C2 Start 93,583,029 bp[2] End 93,589,706 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • RNA binding Cellular component • U4 snRNP • SMN-Sm protein complex • pICln-Sm protein complex • cell nucleus • U7 snRNP • catalytic step 2 spliceosome • U1 snRNP • cytoplasm • small nucleolar ribonucleoprotein complex • nucleoplasm • small nuclear ribonucleoprotein complex • U12-type spliceosomal complex • methylosome • cytosol • spliceosomal complex • U2-type catalytic step 2 spliceosome • U4/U6 x U5 tri-snRNP complex • U2-type precatalytic spliceosome Biological process • termination of RNA polymerase II transcription • histone mRNA metabolic process • mRNA processing • mRNA splicing, via spliceosome • RNA splicing • nuclear import • spliceosomal snRNP assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6636	69878
Ensembl	ENSG00000139343	ENSMUSG00000020018
UniProt	P62306	P62307
RefSeq (mRNA)	NM_003095	NM_027246
RefSeq (protein)	NP_003086	NP_081522
Location (UCSC)	Chr 12: 95.86 – 95.9 Mb	Chr 10: 93.58 – 93.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Small nuclear ribonucleoprotein polypeptide F has been shown to interact with DDX20,[7] Small nuclear ribonucleoprotein D2[8] and Small nuclear ribonucleoprotein polypeptide E.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000139343 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020018 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Lührmann R (May 1995). "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". The EMBO Journal. 14 (9): 2076–88. doi:10.1002/j.1460-2075.1995.tb07199.x. PMC 398308. PMID 7744013.
6. "Entrez Gene: SNRPF small nuclear ribonucleoprotein polypeptide F".
7. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
8. Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.

Further reading

• Sauterer RA, Goyal A, Zieve GW (January 1990). "Cytoplasmic assembly of small nuclear ribonucleoprotein particles from 6 S and 20 S RNA-free intermediates in L929 mouse fibroblasts". The Journal of Biological Chemistry. 265 (2): 1048–58. PMID 1688550.
• Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (April 1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles". The Journal of Biological Chemistry. 264 (10): 5776–83. PMID 2522439.
• Woppmann A, Rinke J, Lührmann R (December 1988). "Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ". Nucleic Acids Research. 16 (23): 10985–1004. doi:10.1093/nar/16.23.10985. PMC 338992. PMID 2974540.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Plessel G, Lührmann R, Kastner B (January 1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core". Journal of Molecular Biology. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
• Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (February 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403. S2CID 17379935.
• Bühler D, Raker V, Lührmann R, Fischer U (December 1999). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy". Human Molecular Genetics. 8 (13): 2351–7. doi:10.1093/hmg/8.13.2351. PMID 10556282.
• Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (March 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". The Journal of Cell Biology. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
• Urlaub H, Raker VA, Kostka S, Lührmann R (January 2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". The EMBO Journal. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
• Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (March 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
• Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". The Journal of Biological Chemistry. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R (June 2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
• Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (June 2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure. 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.