Toby Gibson

Toby James Gibson is a group leader and biochemist at the European Molecular Biology Laboratory (EMBL) in Heidelberg[2][6] known for his work on Clustal.[1][7] According to Nature, Gibson's co-authored papers describing Clustal[7][8] are among the top ten most highly cited scientific papers of all time.[9]

Toby Gibson
Born	Toby James Gibson
Alma mater	University of Edinburgh (BSc) University of Cambridge (PhD)
Known for	Clustal[1]
Scientific career
Fields	Computational biology Bioinformatics Short linear motifs Protein interactions Sequence alignment[2]
Institutions	Laboratory of Molecular Biology European Molecular Biology Laboratory
Thesis	Studies on the Epstein-Barr virus genome (1984)
Influences	Sydney Brenner[3]
Influenced	Ewan Birney[4][5]
Website	www.embl.de/research/units/scb/gibson

Education

Gibson was educated at the University of Edinburgh[3] and went on to his PhD at the University of Cambridge in 1984 on the genome of the Epstein–Barr virus[10] while working in the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB).[3]

Career and research

Gibson was a postdoctoral research fellow with Sydney Brenner before moving to EMBL in 1986.[3] He was appointed a staff scientist in 1991 and a team leader in 1996 where he has worked since.

Gibson’s research interests are in computational biology, bioinformatics, short linear motifs, protein–protein interactions and biological sequence alignment.[2] His laboratory developed and hosts the Eukaryotic Linear Motif (ELM) resource.[11]

References

1. Thompson, Julie D.; Higgins, Desmond G.; Gibson, Toby J. (1994). "CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice". Nucleic Acids Research. 22 (22): 4673–4680. doi:10.1093/nar/22.22.4673. ISSN 0305-1048. PMC 308517. PMID 7984417.
2. Toby Gibson publications indexed by Google Scholar
3. Anon (2019). "Toby (James) Gibson: EMBL, Heidelberg, Germany". uni-halle.de. Martin Luther University of Halle-Wittenberg. Archived from the original on 2019-07-05.
4. Birney, Ewan; Thompson, Julie; Gibson, Toby (1996). "PairWise and SearchWise: Finding the optimal alignment in a simultaneous comparison of a protein profile against all DNA translation frames". Nucleic Acids Research. 24 (14): 2730–2739. doi:10.1093/nar/24.14.2730. PMC 145991. PMID 8759004.
5. Birney, Ewan (2018). "About - Ewan's Blog: Bioinformatician at large". ewanbirney.com.
6. Toby Gibson publications from Europe PubMed Central
7. Thompson, J. (1997). "The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools". Nucleic Acids Research. 25 (24): 4876–4882. doi:10.1093/nar/25.24.4876. ISSN 1362-4962. PMC 147148. PMID 9396791.
8. Thompson, J. D.; Higgins, D. G.; Gibson, T. J. (1994). "CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice". Nucleic Acids Research. 22 (22): 4673–4680. doi:10.1093/nar/22.22.4673. PMC 308517. PMID 7984417.
9. Van Noorden, R.; Maher, B.; Nuzzo, R. (2014). "The top 100 papers: Nature explores the most-cited research of all time". Nature. 514 (7524): 550–3. doi:10.1038/514550a. PMID 25355343.
10. Gibson, Toby James (1984). Studies on the Epstein-Barr virus genome. cam.ac.uk (PhD thesis). University of Cambridge. OCLC 499859334. EThOS uk.bl.ethos.352786.
11. Kumar, Manjeet; Gouw, Marc; Michael, Sushama; Sámano-Sánchez, Hugo; Pancsa, Rita; Glavina, Juliana; Diakogianni, Athina; Valverde, Jesús Alvarado; Bukirova, Dayana; Čalyševa, Jelena; Palopoli, Nicolas; Davey, Norman E; Chemes, Lucía B; Gibson, Toby J (2019). "ELM—the eukaryotic linear motif resource in 2020". Nucleic Acids Research. doi:10.1093/nar/gkz1030. ISSN 0305-1048. PMID 31680160.