Viktor Hamburger

Viktor Hamburger (July 9, 1900 – June 12, 2001)[1][2] was a German-American professor and embryologist. His collaboration with neuroscientist Rita Levi-Montalcini resulted in the discovery of nerve growth factor.[3] In 1951 he and Howard Hamilton in 1951 published a standardized stage series to describe chicken embryo development, now called the Hamburger-Hamilton stages. He was considered "one of the most influential neuroembryologists of the twentieth century".[2]

Viktor Hamburger
Born(1900-07-09)July 9, 1900
Landeshut, Silesia
DiedJune 12, 2001(2001-06-12) (aged 100)
St. Louis, Missouri
NationalityGerman
Alma materUniversity of Freiburg
Known forNerve growth factor
Scientific career
FieldsEmbryology
InstitutionsWashington University in St. Louis
Doctoral advisorHans Spemann

Early life

Hamburger was born on (1900-07-09)July 9, 1900 in Landeshut, Silesia, Germany to Max Hamburger and Else Gradenwitz.[4] After completing gymnasium in June 1918, Hamburger was inducted into the German army, but was released after the Armistice later that year. The army had discharged him in the city of Breslau, and he began his university studies there, moving to Heidelberg for the academic year of 1919–1920. However, in the spring of 1920 he was attracted to move to Freiburg, where he went on to complete his Ph.D. in the laboratory of embryologist Hans Spemann in 1925.[2]

Career

Hamburger was doing post-doctoral research at the University of Chicago when the Nazis came to power in Germany, and was able to remain in the US through the assistance of the Rockefeller Foundation.[2]

Hamburger began to work at Washington University in St. Louis in 1935; he retired from his professor position in 1969 and continued researching until the 1980s.[5][2]

In 1947 Hamburger recognized and brought to the United States a post-doctoral fellow named Rita Levi-Montalcini. Their subsequent collaboration resulted in the discovery of nerve growth factor. This work was continued by Dr. Levi-Montalcini and Dr. Cohen to which they would be awarded the 1986 Nobel Prize in Physiology or Medicine. Dr. Hamburger was excluded as a recipient for the Nobel Prize, although the NGF work by Dr. Levi-Montalcini and Dr. Cohen was based upon work by Dr. Hamburger and was carried out in his laboratory at Washington University St. Louis. Dr. Levi-Montalcini also publicly marginalized Hamburger’s role in the NGF work.[2][3]

In 1951 Hamburger and Howard Hamilton in 1951 published the Hamburger-Hamilton stages. They believed developmental biologists should have a well-grounded reference system to identify the stages of embryo development. This would facilitate comparisons between experiments in different laboratories. The devised their stage series based on visible anatomical characteristics, chosen on the basis of clearly identifiable external features and that the successive stages should be spaced closely together as possible and include quantitative measurements, such a beak or toe length.[2]

In the 1960s, Hamburger did embryological work that established that chick movements in embryo were spontaneous patterns, a finding that contradicted contemporary assertions of behavioral psychologists.[5][6]

Hamburger later revisited nerve growth factor, demonstrating that it was required for the maintenance of neural cells.[7]

Selected awards

References
Notes
  1. Noden, Drew M. (2001). "Viktor Hamburger (1900–2001)". Trends in Neurosciences. Society for Developmental Biology. 24 (11): 673–4. doi:10.1016/s0166-2236(00)01961-5. PMID 11672814. S2CID 40956799. Retrieved 2008-05-09.
  2. Garland E. Allen. Viktor Hamburger, 1900–2001. National Academy of Sciences Biographical Memoirs, 2015, 39 pp.
  3. Cowan, W. M. (2001). "Viktor Hamburger Andrita Levi-Montalcini: The Path to the Discovery of Nerve Growth Factor". Annual Review of Neuroscience. 24: 551–600. doi:10.1146/annurev.neuro.24.1.551. PMID 11283321.
  4. Hamburger, Viktor (1996). "Viktor Hamburger". In Squire, Larry R. (ed.). The history of neuroscience in autobiography. Washington DC: Society for Neuroscience. p. 223. ISBN 0-916110-51-6. Retrieved 2013-08-05.
  5. Freeman, Karen (2001-06-14). "Viktor Hamburger, 100, Dies; Embryologist Revealed Architecture of Nervous System". The New York Times. ISSN 0362-4331. Retrieved 2013-05-26.
  6. Hamburger, V.; Wenger, E.; Oppenheim, R. (1966). "Motility in the chick embryo in the absence of sensory input". Journal of Experimental Zoology. 162 (2): 133. doi:10.1002/jez.1401620202.
  7. Navis, Adam R. (2012-05-08). "Viktor Hamburger". Embryo Project Encyclopedia. Tempe, Arizona: Arizona State University, School of Life Sciences, Center for Biology and Society. Retrieved 2013-05-26.
  8. http://www.uu.se/en/about-uu/traditions/prizes/honorary-doctorates/
Bibliography
  • Hamburger, Viktor (1996). "Viktor Hamburger". In Squire, Larry R. (ed.). The history of neuroscience in autobiography. Washington DC: Society for Neuroscience. pp. 222‒250. ISBN 0-916110-51-6. Retrieved 2013-05-26.


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