CEP104

Centrosomal protein 104kDa is a protein that in humans is encoded by the CEP104 gene. [5] Like its Chlamydomonas ortholog, FAP256, it has been shown to localize to the distal ends of both centrioles in the absence of a cilium. During cilium formation, it is found at the tip of the elongating cilium.[6]

CEP104
Identifiers
Aliases	CEP104, GlyBP, KIAA0562, CFAP256, JBTS25, ROC22, centrosomal protein 104
External IDs	OMIM: 616690 MGI: 2687282 HomoloGene: 44919 GeneCards: CEP104
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.32 Start 3,812,081 bp[1] End 3,857,214 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 153,975,194 bp[2] End 154,008,732 bp[2]
Orthologs
Species	Human	Mouse
Entrez	9731	230967
Ensembl	ENSG00000116198	ENSMUSG00000039523
UniProt	O60308	Q80V31
RefSeq (mRNA)	NM_014704	NM_177673
RefSeq (protein)	NP_055519	NP_808341
Location (UCSC)	Chr 1: 3.81 – 3.86 Mb	Chr 4: 153.98 – 154.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000116198 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039523 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Centrosomal protein 104kDa". Retrieved 2014-06-04.
6. Satish Tammana TV, Tammana D, Diener DR, Rosenbaum J (November 2013). "Centrosomal protein CEP104 (Chlamydomonas FAP256) moves to the ciliary tip during ciliary assembly". Journal of Cell Science. 126 (Pt 21): 5018–29. doi:10.1242/jcs.133439. PMC 3820246. PMID 23970417.

External links

• Human CEP104 genome location and CEP104 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: O60308 (Centrosomal protein of 104 kDa) at the PDBe-KB.

Further reading

• Kumar KN, Babcock KK, Johnson PS, Chen X, Ahmad M, Michaelis EK (November 1995). "Cloning of the cDNA for a brain glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein". Biochemical and Biophysical Research Communications. 216 (1): 390–8. doi:10.1006/bbrc.1995.2636. PMID 7488117.
• Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I, Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA, Andersen JS (April 2011). "Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods". The EMBO Journal. 30 (8): 1520–35. doi:10.1038/emboj.2011.63. PMC 3102290. PMID 21399614.