HLA-B42

HLA-B42 (B42) is an HLA-B serotype. The serotype identifies the HLA-B*4201 and *4202 gene products.[1] HLA-B*4201 is common in Central Africa. (For terminology help see: HLA-serotype tutorial)




major histocompatibility complex (human), class I, B42
Alleles	B4201 B4202
Structure (See HLA-B)
Symbol(s)	HLA-B
EBI-HLA	B*4201
EBI-HLA	B*4202
Locus	chr.6 6p21.31

Serotype

B42 serotype recognition of Some HLA B*42 allele-group gene products[2]
B*42	B42	other	Sample
allele	%	%	size (N)
4201	93	2	1015
4202	95		80

Serological typing for B*4201 and B*4202 is relatively efficient.

B*4201 allele frequencies

**HLA B*4201 frequencies**
		freq
ref.	Population	(%)
[3]	Zambia Lusaka	14.8
[3]	Mali Bandiagara	13.8
[3]	Burkina Faso Mossi	13.2
[3]	South African Natal Zulu	12.0
[3]	Burkina Faso Rimaibe	9.6
[3]	South Africa Tswana	8.5
[3]	Kenya Luo	7.7
[3]	Kenya	7.3
[3]	Kenya Nandi	6.9
[3]	Zimbabwe Harare Shona	6.9
[3]	Saudi Arabia	5.6
[3]	Cameroon Yaounde	4.9
[3]	Cameroon Beti	4.0
[3]	Cameroon Bamileke	3.9
[3]	Cameroon Sawa	3.8
[3]	Ivory Coast Akan Adiopodoume	3.4
[3]	Israel Gaza Palestinians	2.4
[3]	India North Delhi	2.2
[3]	Senegal Niokholo Mandenka	1.6
[3]	Mbenzele Pygmy (C. Afr. Rep.)	1.5
[3]	Iran Baloch	1.5
[3]	Pakistan Baloch	1.5
[3]	Sudanese	1.5
[3]	Tunisia	1.5
[3]	Pakistan Brahui	1.4
[3]	Cameroon Bamileke	1.3
[3]	Oman	1.3
[3]	Sudanese	1.3
[3]	Tunisia Tunis	1.1
[3]	Zimbabwe Harare Shona	1.1
[3]	Cameroon Bakola Pygmy	1.0
[3]	Pakistan Pathan	1.0
[3]	Portugal Centre	1.0
[3]	Saudi Arabia Guraiat and Hail	1.0
[3]	Morocco Casablanca	0.9
[3]	Senegal Dakar	0.9
[3]	Uganda Kampala	0.9
[3]	Cape Verde Southeastern Islands	0.8
[3]	Guinea Bissau	0.8
[3]	United Arab Emerates	0.8
[3]	Morocco Nador Metalsa Class I	0.7
[3]	Pakistan Karachi Parsi	0.6
[3]	Spain Majorca	0.6
[3]	China Yunnan Han pop2	0.5
[3]	England Newcastle	0.5
[3]	Israel Arab Druse	0.5
[3]	Israel Jews	0.5
[3]	Italy Rome	0.5
[3]	Guadalajara Mestizos (2) (Mexico)	0.5
[3]	Morocco	0.5
[3]	Pakistan Sindhi	0.5
[3]	Senegal Niokholo Mandenka	0.5
[3]	Singapore Riau Malay	0.5

References

Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
derived from IMGT/HLA
Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)

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[pmid15787720-1] Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.

[2] rived from IMGT/HLA

[pmid12753660-3] Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)