HLA-B54

HLA-B54 (B54) is an HLA-B serotype. B54 is a split antigen from the B22 broad antigen, sister serotypes are B55 and B56.[1] The serotype identifies the more common HLA-B*55 gene products.[2]

major histocompatibility complex (human), class I, B54
Alleles	B*5401
Structure (See HLA-B)
Symbol(s)	HLA-B
EBI-HLA	B*5401
Locus	chr.6 6p21.31

Serotype

B54 and B22 serotype recognition of HLA B*5401 allele[3]

B*54	B54	B22	Sample
allele	%	%	size (N)
5401	67	3	631

Allele distribution

HLA B*5401 frequencies

		freq
ref.	Population	(%)
[4]	USA Hawaii Okinawa	10.6
[4]	Japan Central	7.7
[4]	South Korea (3)	5.9
[4]	China Guangzhou	4.5
[4]	Thailand (3)	4.1
[4]	China Inner Mongolia	3.4
[4]	China North Han	3.3
[4]	China Beijing Shijiazhuang Tianjian Han	3.0
[4]	China South Han	2.5
[4]	Russia Tuva pop 2	2.2
[4]	China Guangxi Maonan	1.9
[4]	Thailand	1.8
[4]	Taiwan Thao	1.7
[4]	China Tibet Autonomous Region Tibetans	1.3

See also

• HLA-serotype tutorial

References

1. Hildebrand, W. H.; Madrigal, J. A.; Little, A. M.; Parham, P. (1992). "HLA-Bw22: a family of molecules with identity to HLA-B7 in the alpha 1-helix". Journal of Immunology. 148 (4): 1155–1162. PMID 1737933.
2. Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
3. derived from IMGT/HLA
4. Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.