HLA-B67

HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products.[1] B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim (Taiwan, Japan, Korea, Coastal Siberia), and B7, B22, or B27.[2] (For terminology help see: HLA-serotype tutorial)




major histocompatibility complex (human), class I, B67
Alleles	B*6701
Structure (See HLA-B)
Symbol(s)	HLA-B
EBI-HLA	B*6701
Locus	chr.6 6p21.31

Serotype

B67 Serotype recognition of the B*67 allele-group gene products[3]
B*67	B67	Other	Sample
allele	%	%	size (N)
6701	32	62	81

By allele

**Regions of higher B*6701 frequency**
Japan
Taiwan
Heilongjiang province, China (Harbin city)
Beijing China
Shandong peninsula

**HLA B*6701 frequencies**
		freq
ref.	Population	(%)
[4]	Osaka Region (Japan)	2.6
[4]	Hakka (Taiwan)	1.8
[4]	Japan (5)	1.7
[4]	Harbin Man (China)	1.7
[4]	Beijing (China)	1.5
[4]	Linqu (Shandong, China)	1.1
[4]	Siraya (Taiwan)	1.0
[4]	Portugal South	1.0
[4]	Oold (Mongolia)	1.0
[4]	American Samoa	1.0
[4]	Pazeh (Taiwan)	0.9
[4]	South Korea (3)	0.9
[4]	N. Korean (Harbin,China)	0.8
[4]	Arratia Basque (Spain)	0.6
[4]	Tarialan Khoton (Mongolia)	0.6
[4]	Shanghai (China)	0.6
[4]	Natal Zulu (South African)	0.5
[4]	Yunnan Han (China)	0.5
[4]	Turkey	0.4
[4]	Southern Han (China)	0.4
[4]	Tuva (Russia)	0.3
[4]	Chinese (Hong Kong, China)	0.1

References

Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
Little AM, Domena JD, Hildebrand WH, et al. (1994). "HLA-B67: a member of the HLA-B16 family that expresses the ME1 epitope". Tissue Antigens. 43 (1): 38–43. doi:10.1111/j.1399-0039.1994.tb02294.x. PMID 7517584.
derived from IMGT/HLA
Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)

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[pmid15787720-1] Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.

[pmid7517584-2] Little AM, Domena JD, Hildebrand WH, et al. (1994). "HLA-B67: a member of the HLA-B16 family that expresses the ME1 epitope". Tissue Antigens. 43 (1): 38–43. doi:10.1111/j.1399-0039.1994.tb02294.x. PMID 7517584.

[3] rived from IMGT/HLA

[pmid12753660-4] Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)