List of opioids

This is a list of opioids, opioid antagonists and inverse agonists.

Opium poppy (Papaver somniferum) flower

Opium and poppy straw derivatives
Seedhead of opium poppy with white latex

Crude opiate extracts whole opium products

Opium alkaloids
Structures
Morphides
Codeine Morphine Oripavine Pseudomorphine Thebaine

Alkaloid salts mixtures

Morphine family
Structures of Morphine family
Morphine family
14-Hydroxymorphine 2,4-Dinitrophenylmorphine 6-Methyldihydromorphine 6-Methylenedihydrodesoxymorphine 6-Acetyldihydromorphine hydrochloride
Azidomorphine Chlornaltrexamine Chloroxymorphamine Desomorphine
(Dihydrodesoxymorphine)		 Dihydromorphine
Ethyldihydromorphine Hydromorphinol Methyldesorphine N-Phenethylnormorphine 6-nicotinoyldihydromorphine
RAM-378

3,6-diesters of morphine
Structures
3,6-diesters of morphine
Acetylpropionylmorphine 3,6-Dibutanoylmorphine Diacetyldihydromorphine
(dihydroheroin, acetylmorphinol)
Dibutyrylmorphine Dibenzoylmorphine Diformylmorphine
Dipropanoylmorphine Heroin
(diacetylmorphine)		 Nicomorphine

Codeine-dionine family
Structures
Codeine-dionine family
6-Monoacetylcodeine Benzylmorphine Codeine methylbromide Desocodeine Dimethylmorphine
(6-O-Methylcodeine)
Ethyldihydromorphine Methyldihydromorphine
(dihydroheterocodeine)		 Ethylmorphine Heterocodeine Isocodeine
Pholcodine Myrophine Transisocodeine

Morphinones and morphols
Structures
Morphinones and morphols
14-Cinnamoyloxycodeinone 14-Ethoxymetopon 14-Methoxymetopon 14-Phenylpropoxymetopon 7-Spiroindanyloxymorphone
8,14-Dihydroxydihydromorphinone Acetylcodone Acetylmorphone α-hydrocodol
(Dihydrocodeine)		 Bromoisopropropyldihydromorphinone
Codeinone Codorphone Codol
(Codeine Phosphate)		 Codoxime IBNtxA
Thebacon Hydrocodone Hydromorphone Hydroxycodeine Metopon
(methyldihydromorphinone)
Morphenol Morphinone Morphol N-Phenethyl-14-ethoxymetopon Oxycodone
Oxymorphol Oxymorphone Pentamorphone Semorphone

Morphides
  • α-Chlorocodide (= chlorocodide) 
  • β-Chlorocodide 
  • α-Chloromorphide (= chloromorphide)
  • Bromocodide 
  • Bromomorphide 
  • Chlorodihydrocodide 
  • Chloromorphide
  • Codide 
Structures
Morphides
α-chlorocodide β-chlorocodide Bromomorphide
Chlorodihydrocodide. Chloromorphide Codide

Dihydrocodeine series
Structures
Morphides
14-Hydroxydihydrocodeine Acetyldihydrocodeine Dihydrocodeine Dihydrodesoxycodeine
Dihydroisocodeine Nicocodeine Nicodicodeine

Nitrogen morphine derivatives
Structures
Morphides
1-Nitrocodeine Codeine-N-oxide Morphine-N-oxide

Hydrazones
Structures
Hydrazones
Oxymorphazone

Halogenated morphine derivatives
Structures
Other open chain opioids

1-Bromocodeine

1-Chlorocodeine

1-Iodomorphine

Active opiate metabolites
Structures
Active opiate metabolites
Codeine-N-oxide Heroin-7,8-oxide Morphine-6-glucuronide 6-Monoacetylmorphine
Morphine-N-oxide Naltrexol Norcodeine Normorphine

Morphinans
Levomethorphan

Morphinan series
Structures
Other morphinans
4-chlorophenylpyridomorphinan Cyclorphan Dextrallorphan Levargorphan Levophenacylmorphan
Levomethorphan Norlevorphanol N-Methylmorphinan Oxilorphan Phenomorphan
Dextromethorphan levomethorphan Morphanol Ro4-1539 Stephodeline Xorphanol

Others
Structures
Other Morphinans
1-Nitroaknadinine 14-episinomenine 5,6-Dihydronorsalutaridine 6-Keto Nalbuphine Aknadinine
Butorphanol Cephakicine Cephasamine Cyprodime Drotebanol
Fenfangjine G Nalbuphine Sinococuline Sinomenine Tannagine

Benzomorphans
Structures
Benzomorphans
5,9 alpha-diethyl-2-hydroxybenzomorphan
(5,9-DEHB)		 8-Carboxamidocyclazocine Alazocine Anazocine Bremazocine
Butinazocine Carbazocine Cogazocine Cyclazocine Dezocine
Eptazocine Etazocine Ethylketocyclazocine Fedotozine Fluorophen
Gemazocine Ibazocine Ketazocine Metazocine Moxazocine
Pentazocine Phenazocine Quadazocine Thiazocine Tonazocine
Volazocine Zenazocine

4-Phenylpiperidines
Pethidine

Pethidines (meperidines)
Structures
Pethidines (meperidines)
4-Fluoromeperidine 8-Carboxamidocyclazocine Allylnorpethidine Anileridine Benzethidine
Carperidine Difenoxin Diphenoxylate Etoxeridine Furethidine
Hydroxypethidine Morpheridine Meperidine-N-oxide Oxpheneridine Pethidine
Pethidine intermediate A Pethidine intermediate B Pethidine intermediate C Pheneridine Phenoperidine
Piminodine Properidine Sameridine

Prodines
Structures
Prodines
Allylprodine (α/β)-Meprodine Desmethylprodine (MPPP) PEPAP Prodine
Prosidol Prosidol

Ketobemidones
Structures
Ketobemidones
Acetoxyketobemidone Droxypropine Ketobemidone Methylketobemidone Propylketobemidone

Others
Structures
Other phenylpiperidines
Alvimopan Loperamide LS-115509 Picenadol

Open chain opioids
Methadone

Amidones
Structures
Amidones

Dextromethadone

Dipipanone

Isomethadone

 Levoisomethadone
Noracetylmethadol Levomethadone Methadone Methadone intermediate
Normethadone Norpipanone Phenadoxone Pipidone

Methadols
Structures
Other open chain opioids

Alphaacetylmethadol

Dimepheptanol

Levacetylmethadol

Noracetylmethadol

Moramides
Structures
Other open chain opioids

Desmethylmoramide

Dextromoramide

Levomoramide

Moramide intermediate

Racemoramide

Thiambutenes
Structures
Thiambutenes

Diethylthiambutene

Dimethylthiambutene

Ethylmethylthiambutene

Piperidylthiambutene

Thiambutene

Tipepidine

Phenalkoxams
Structures
Phenalkoxams

Dextropropoxyphene
(propoxyphene)

Dimenoxadol

Dioxaphetyl butyrate

Levopropoxyphene

Norpropoxyphene

Ampromides
Structures
Ampromides

Diampromide

Phenampromide

Propiram

Others
Structures
Other open chain opioids

Embutramide

IC-26

Isoaminile

Lefetamine

R-4066

Anilidopiperidines
Fentanyl
Structures
Anilidopiperidines
3-Allylfentanyl 3-Methylfentanyl 3-Methylthiofentanyl 4-Phenylfentanyl Alfentanil
Alphamethylacetylfentanyl Alphamethylfentanyl Alphamethylthiofentanyl Benzylfentanyl Betahydroxyfentanyl
Betahydroxythiofentanyl Betamethylfentanyl Brifentanil Carfentanil Fentanyl
Lofentanil Mirfentanil Ocfentanil Ohmefentanyl Parafluorofentanyl
Phenaridine Remifentanil Sufentanil Thenylfentanyl Thiofentanyl
Trefentanil

Oripavine derivatives
Thienorphine
Structures
Oripavine derivatives
7-PET Acetorphine Alletorphine BU-48 Buprenorphine
Cyprenorphine Dihydroetorphine Etorphine Homprenorphine 18,19-Dehydrobuprenorphine
N-cyclopropylmethylnoretorphine Nepenthone Norbuprenorphine Thevinone Thienorphine

Phenazepanes
Structures
Phenazepanes

Ethoheptazine

Meptazinol

Metheptazine

Metethoheptazine

Proheptazine

Pirinitramides
Structures
Pirinitramides

Bezitramide

Piritramide

Benzimidazoles
Structures
Benzimidazoles

Clonitazene

Etonitazene

Isotonitazene

Metonitazene

Nitazene: R = hydrogen

Indoles
Structures
Indoles

18-Methoxycoronaridine

7-Acetoxymitragynine

7-Hydroxymitragynine

Akuammidine

Akuammine

Eseroline

Hodgkinsine

Mitragynine

Pericine

Pseudoakuammigine

Beta-Amino Ketones
  • 3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one
Structures
Indoles

3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one (Beta-amine ketone 'compound 29')

Diphenylmethylpiperazines
Structures
Diphenylmethylpiperazines

BW373U86

DPI-221

DPI-287

DPI-3290

SNC-80

Opioid peptides
β-neo-endorphin

Dynorphins
Structures
Dynorphins
Big dynorphin Dynorphin A Dynorphin B

Endomorphins

Endorphins
Structures
Dynorphins
Beta-endorphin Alpha-endorphin Gamma-endorphin α-neo-endorphin β-neo-endorphin

Enkephalins
Structures
Enkephalins
DADLE DAMGO Dermenkephalin Met-enkephalin Leu-enkephalin

Propeptides

Others / unknown
Structures
Other or unknown opioid peptides
Adrenorphin Amidorphin Casomorphin DALDA Deltorphin
Dermorphin DPDPE Endomorphin-1
Endomorphin-2		 Gliadorphin Morphiceptin
Nociceptin Octreotide Opiorphin Rubiscolin TRIMU 5

Others

Opioid antagonists and inverse agonists

Biased ligands

Receptor heteromer targeting ligands

Uncategorized opioids
Structures
Uncategorized opioids

Alimadol

Anilopam

Asimadoline

FE 200665

Fedotozine

MCOPPB

Nalfurafine

 Nalodeine

Nalorphine

Nalorphine dinicotinate

SoRI-9409

Combination drug formulations containing opioids

See also

References
  1. ChemIndex CAS Registry Number 3371-56-0
  2. ChemIndex CAS Registry Number 509-56-8
  3. ChemIndex CAS Registry Number 63715-94-6
  4. NCBI PubChem SID 750205
  5. chembase cbid_346222
  6. Gomes I, Fujita W, Gupta A, Saldanha SA, Saldanha AS, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA (2013). "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. Bibcode:2013PNAS..11012072G. doi:10.1073/pnas.1222044110. PMC 3718106. PMID 23818586.
  7. Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS (2011). "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. Bibcode:2011PNAS..108.5098Y. doi:10.1073/pnas.1016277108. PMC 3064379. PMID 21385944.
  • Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time." Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740
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