Physalaemin
Physalaemin is a tachykinin peptide obtained from the Physalaemus frog, closely related to substance P. Its structure was first elucidated in 1964.[1][2]
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| ChEMBL | |
| MeSH | Physalaemin |
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| Properties | |
| C58H84N14O16S | |
| Molar mass | 1265.44 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Like all tachykinins, physalaemin is a sialagogue (increases salivation) and a potent vasodilator with hypotensive effects.[3]
References
- Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). "Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Experientia. 20 (9): 489–90. doi:10.1007/BF02154064. PMID 5857249. S2CID 25448266.
- Anastasi A, Erspamer V, Cei JM (1964). "Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Arch Biochem Biophys. 108 (2): 341–8. doi:10.1016/0003-9861(64)90395-9. PMID 14240587.
- Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). "The tachykinin peptide family". Pharmacol Rev. 54 (2): 285–322. doi:10.1124/pr.54.2.285. PMID 12037144. S2CID 85570180.
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