Scintimammography

Scintimammography is a type of breast imaging test that is used to detect cancer cells in the breasts of some women who have had abnormal mammograms, or for those who have dense breast tissue, post-operative scar tissue or breast implants.[1]

Scintimammography
Mammography (left) and DMSA scintimammography (right) images of 4.5cm breast carcinoma
SynonymsNuclear medicine breast imaging
Breast specific gamma imaging
Breast scintigraphy
Molecular breast imaging
ICD-10-PCSCH1
ICD-9-CM92.19
HCPCS-L2S8080

Scintimammography is not used for screening or in place of a mammogram. Rather, it is used when the detection of breast abnormalities is not possible or not reliable on the basis of mammography and ultrasound.[2]

Procedure

In the scintimammography procedure, a woman receives an injection of a small amount of a radioactive substance which is taken up by cancer cells, and a gamma camera is used to take pictures of the breasts.

Technetium-99m sestamibi (99mTc-MIBI) is the most commonly used radiopharmaceutical.[3][4] When performed with MIBI the procedure may also be known as a Miraluma test.[5] The typical dose is 740–1,110 megabecquerels (MBq) with the patient lying prone on the bed for imaging approximately 10 minutes after injection.[6]

99mTc-DMSA and 99mTc-MDP may also been used, but provide less sensitive results.[7]

Equipment

Breast-specific gamma cameras have been developed with a smaller field of view than conventional cameras, allowing higher resolution imagery and compression of the breast as in x-ray mammography (which improves detection of smaller lesions).[8][9]

See also

References
  1. Liberman, Moishe; Sampalis, Fotini; Mulder, David S.; Sampalis, John S. (2003). "Breast Cancer Diagnosis by Scintimammography: A Meta-analysis and Review of the Literature". Breast Cancer Research and Treatment. 80 (1): 115–126. doi:10.1023/A:1024417331304. ISSN 0167-6806. PMID 12889605. S2CID 10769269.
  2. Taillefer, Raymond (January 1999). "The role of 99mTc-sestamibi and other conventional radiopharmaceuticals in breast cancer diagnosis". Seminars in Nuclear Medicine. 29 (1): 16–40. doi:10.1016/S0001-2998(99)80027-0. PMID 9990681.
  3. Salvatore, Marco; Del Vecchio, Silvana (May 1998). "Dynamic imaging: scintimammography". European Journal of Radiology. 27: S259–S264. doi:10.1016/S0720-048X(98)00072-2. PMID 9652532.
  4. Nass, Sharyl J.; Henderson, I. Craig; Cancer, Institute of Medicine (U.S.). Committee on Technologies for the Early Detection of Breast (2001). Mammography and beyond: developing technologies for the early detection of breast cancer. National Academies Press. pp. 106–. ISBN 978-0-309-07283-0. Retrieved 17 July 2011.
  5. Tartar, Marie; Comstock, Christopher E.; Kipper, Michael S. (2008). Breast cancer imaging: a multidisciplinary, multimodality approach. Elsevier Health Sciences. pp. 88–. ISBN 978-0-323-04677-0. Retrieved 18 July 2011.
  6. "Procedure Guideline for Breast Scintigraphy" (PDF). Society of Nuclear Medicine. 2004. Cite journal requires |journal= (help)
  7. Piccart, Martine; Wood, William C.; Hung, Chie-Mien; Solin, Lawrence J.; Cardoso, Fatima (2007-03-07). Breast Cancer Management and Molecular Medicine. Springer Science & Business Media. p. 36. ISBN 9783540282655.
  8. Fass, Leonard (August 2008). "Imaging and cancer: A review". Molecular Oncology. 2 (2): 115–152. doi:10.1016/j.molonc.2008.04.001. PMC 5527766. PMID 19383333.
  9. Goldsmith, S. J.; Parsons, W.; Guiberteau, M. J.; Stern, L. H.; Lanzkowsky, L.; Weigert, J.; Heston, T. F.; Jones, E.; Buscombe, J.; Stabin, M. G. (5 November 2010). "SNM Practice Guideline for Breast Scintigraphy with Breast-Specific γ-Cameras 1.0". Journal of Nuclear Medicine Technology. 38 (4): 219–224. doi:10.2967/jnmt.110.082271. PMID 21057112.

 This article incorporates public domain material from the U.S. National Cancer Institute document: "Dictionary of Cancer Terms".


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