TUBGCP2

Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene.[5][6] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

TUBGCP2
Identifiers
Aliases	TUBGCP2, GCP-2, GCP2, Grip103, SPBC97, Spc97p, h103p, hGCP2, hSpc97, tubulin gamma complex associated protein 2, ALP4, SPC97, PAMDDFS
External IDs	OMIM: 617817 MGI: 1921487 HomoloGene: 55980 GeneCards: TUBGCP2
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 133,278,630 bp[1] End 133,312,337 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F4 Start 139,995,955 bp[2] End 140,036,669 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural constituent of cytoskeleton • GO:0001948 protein binding • microtubule minus-end binding • gamma-tubulin binding Cellular component • cytoplasm • cytosol • centrosome • spindle pole • equatorial microtubule organizing center • membrane • nucleoplasm • microtubule organizing center • gamma-tubulin small complex • spindle pole body • cytoplasmic microtubule • cytoskeleton • microtubules • gamma-tubulin complex Biological process • centrosome duplication • interphase microtubule nucleation by interphase microtubule organizing center • mitotic spindle assembly • cytoplasmic microtubule organization • microtubule cytoskeleton organization • microtubule nucleation • GO:0007126 meiotic cell cycle • GO:0007067 mitotic cell cycle • spindle assembly • macromolecular complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10844	74237
Ensembl	ENSG00000130640	ENSMUSG00000025474
UniProt	Q9BSJ2	Q921G8
RefSeq (mRNA)	NM_001256617 NM_001256618 NM_006659	NM_001286007 NM_001286009 NM_001286011 NM_133755
RefSeq (protein)	NP_001243546 NP_001243547 NP_006650	NP_001272936 NP_001272938 NP_001272940 NP_598516
Location (UCSC)	Chr 10: 133.28 – 133.31 Mb	Chr 7: 140 – 140.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tubulin
• TUBGCP3
• TUBGCP4
• TUBGCP5
• TUBGCP6

References

1. GRCh38: Ensembl release 89: ENSG00000130640 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025474 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Murphy SM, Urbani L, Stearns T (Jun 1998). "The Mammalian γ-Tubulin Complex Contains Homologues of the Yeast Spindle Pole Body Components Spc97p and Spc98p". J Cell Biol. 141 (3): 663–74. doi:10.1083/jcb.141.3.663. PMC 2132743. PMID 9566967.
6. "Entrez Gene: TUBGCP2 tubulin, gamma complex associated protein 2".

Further reading

• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takahashi M, Yamagiwa A, Nishimura T, et al. (2003). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
• Murphy SM, Preble AM, Patel UK, et al. (2002). "GCP5 and GCP6: Two New Members of the Human γ-Tubulin Complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.