TUBGCP6

Gamma-tubulin complex component 6 is a protein that in humans is encoded by the TUBGCP6 gene.[5][6][7] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

TUBGCP6
Identifiers
Aliases	TUBGCP6, GCP-6, GCP6, MCCRP, MCPHCR, MCCRP1, tubulin gamma complex associated protein 6
External IDs	OMIM: 610053 MGI: 2146071 HomoloGene: 32477 GeneCards: TUBGCP6
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.33 Start 50,217,689 bp[1] End 50,245,023 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E3 Start 89,098,357 bp[2] End 89,123,112 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • microtubule binding • structural constituent of cytoskeleton • microtubule minus-end binding • gamma-tubulin binding Cellular component • cytoplasm • cytosol • centrosome • spindle pole • equatorial microtubule organizing center • membrane • microtubule organizing center • spindle pole body • gamma-tubulin ring complex • microtubules • extracellular exosome • cytoskeleton • gamma-tubulin complex • gamma-tubulin small complex Biological process • centrosome duplication • interphase microtubule nucleation by interphase microtubule organizing center • mitotic spindle assembly • cytoplasmic microtubule organization • microtubule cytoskeleton organization • microtubule nucleation • GO:0007126 meiotic cell cycle • GO:0007067 mitotic cell cycle • spindle assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85378	328580
Ensembl	ENSG00000128159	ENSMUSG00000051786
UniProt	Q96RT7	G5E8P0
RefSeq (mRNA)	NM_001008658 NM_020461	NM_001163319
RefSeq (protein)	NP_065194	NP_001156791
Location (UCSC)	Chr 22: 50.22 – 50.25 Mb	Chr 15: 89.1 – 89.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tubulin
• TUBGCP2
• TUBGCP3
• TUBGCP4
• TUBGCP5

References

1. GRCh38: Ensembl release 89: ENSG00000128159 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051786 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
6. Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
7. "Entrez Gene: TUBGCP6 tubulin, gamma complex associated protein 6".

Further reading

• Oriolo AS, Wald FA, Canessa G, Salas PJ (2007). "GCP6 binds to intermediate filaments: a novel function of keratins in the organization of microtubules in epithelial cells". Mol. Biol. Cell. 18 (3): 781–94. doi:10.1091/mbc.E06-03-0201. PMC 1805110. PMID 17182859.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.