TUBGCP4

Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene.[5] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

TUBGCP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RIP
Identifiers
Aliases	TUBGCP4, 76P, GCP-4, GCP4, Grip76, MCCRP3, tubulin gamma complex associated protein 4
External IDs	OMIM: 609610 MGI: 1196293 HomoloGene: 8690 GeneCards: TUBGCP4
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.3 Start 43,369,221 bp[1] End 43,409,771 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E5|2 60.37 cM Start 121,170,654 bp[2] End 121,198,770 bp[2]
Gene ontology Molecular function • structural constituent of cytoskeleton • microtubule minus-end binding • GO:0001948 protein binding • gamma-tubulin binding Cellular component • cytoplasm • microtubule organizing center • gamma-tubulin complex • cytosol • spindle pole body • spindle pole • recycling endosome • equatorial microtubule organizing center • gamma-tubulin ring complex • membrane • microtubules • microtubule cytoskeleton • cytoskeleton • centrosome Biological process • interphase microtubule nucleation by interphase microtubule organizing center • microtubule cytoskeleton organization • mitotic spindle assembly • centrosome duplication • cytoplasmic microtubule organization • microtubule nucleation • GO:0007126 meiotic cell cycle • GO:0007067 mitotic cell cycle • spindle assembly • macromolecular complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27229	51885
Ensembl	ENSG00000137822	ENSMUSG00000027263
UniProt	Q9UGJ1	Q9D4F8
RefSeq (mRNA)	NM_001286414 NM_014444	NM_001290824 NM_153387
RefSeq (protein)	NP_001273343 NP_055259	NP_001277753 NP_700436
Location (UCSC)	Chr 15: 43.37 – 43.41 Mb	Chr 2: 121.17 – 121.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tubulin
• TUBGCP2
• TUBGCP3
• TUBGCP5
• TUBGCP6

References

1. GRCh38: Ensembl release 89: ENSG00000137822 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027263 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Tubulin, gamma complex associated protein 4".

Further reading

• Hsu HL, Yeh NH (February 1996). "Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis". Journal of Cell Science. 109 ( Pt 2) (2): 277–88. PMID 8838651.
• Haren L, Merdes A (May 2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules". Journal of Cell Science. 115 (Pt 9): 1815–24. PMID 11956313.
• Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (November 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Molecular Biology of the Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
• Fava F, Raynaud-Messina B, Leung-Tack J, Mazzolini L, Li M, Guillemot JC, Cachot D, Tollon Y, Ferrara P, Wright M (November 1999). "Human 76p: A new member of the gamma-tubulin-associated protein family". The Journal of Cell Biology. 147 (4): 857–68. doi:10.1083/jcb.147.4.857. PMC 2156165. PMID 10562286.
• Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (September 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Molecular Biology of the Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.