TUBGCP3

Gamma-tubulin complex component 3 is a protein that in humans is encoded by the TUBGCP3 gene.[5][6][7] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

TUBGCP3
Identifiers
Aliases	TUBGCP3, 104p, GCP3, Grip104, SPBC98, Spc98, Spc98p, tubulin gamma complex associated protein 3, ALP6
External IDs	OMIM: 617818 MGI: 2183752 HomoloGene: 4609 GeneCards: TUBGCP3
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q34 Start 112,485,011 bp[1] End 112,588,205 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.1 Start 12,614,277 bp[2] End 12,672,248 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural molecule activity • structural constituent of cytoskeleton • GO:0001948 protein binding • microtubule minus-end binding • gamma-tubulin binding Cellular component • cytoplasm • cytosol • centrosome • spindle pole • equatorial microtubule organizing center • membrane • spindle • microtubule organizing center • gamma-tubulin small complex • polar microtubule • spindle pole body • centriole • cytoskeleton • microtubules • gamma-tubulin complex Biological process • centrosome duplication • interphase microtubule nucleation by interphase microtubule organizing center • single fertilization • mitotic spindle assembly • cytoplasmic microtubule organization • microtubule cytoskeleton organization • microtubule nucleation • GO:0007126 meiotic cell cycle • GO:0007067 mitotic cell cycle • spindle assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10426	259279
Ensembl	ENSG00000282003 ENSG00000126216	ENSMUSG00000000759
UniProt	Q96CW5	P58854
RefSeq (mRNA)	NM_001286277 NM_001286278 NM_001286279 NM_006322	NM_198031
RefSeq (protein)	NP_001273206 NP_001273207 NP_001273208 NP_006313	NP_932148
Location (UCSC)	Chr 13: 112.49 – 112.59 Mb	Chr 8: 12.61 – 12.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tubulin
• TUBGCP2
• TUBGCP4
• TUBGCP5
• TUBGCP6

References

1. ENSG00000126216 GRCh38: Ensembl release 89: ENSG00000282003, ENSG00000126216 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000759 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Murphy SM, Urbani L, Stearns T (Jun 1998). "The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p". J Cell Biol. 141 (3): 663–74. doi:10.1083/jcb.141.3.663. PMC 2132743. PMID 9566967.
6. Tassin AM, Celati C, Moudjou M, Bornens M (Jun 1998). "Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin". J Cell Biol. 141 (3): 689–701. doi:10.1083/jcb.141.3.689. PMC 2132749. PMID 9566969.
7. "Entrez Gene: TUBGCP3 tubulin, gamma complex associated protein 3".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takahashi M, Yamagiwa A, Nishimura T, et al. (2003). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
• Murphy SM, Preble AM, Patel UK, et al. (2002). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.