WNT8B

Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene.[5][6]

WNT8B
Identifiers
Aliases	WNT8B, Wnt family member 8B
External IDs	OMIM: 601396 MGI: 109485 HomoloGene: 2550 GeneCards: WNT8B
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.31 Start 100,463,009 bp[1] End 100,483,744 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 37.98 cM Start 44,493,472 bp[2] End 44,514,273 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor binding • GO:0005110 frizzled binding • receptor ligand activity Cellular component • extracellular region • extracellular Biological process • multicellular organism development • cellular response to retinoic acid • cell fate commitment • determination of dorsal identity • response to estradiol • gastrulation • response to retinoic acid • neuron differentiation • signal transduction • nervous system development • beta-catenin destruction complex disassembly • Wnt signaling pathway • regulation of receptor activity • canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7479	22423
Ensembl	ENSG00000075290	ENSMUSG00000036961
UniProt	Q93098	Q9WUD6
RefSeq (mRNA)	NM_003393	NM_011720
RefSeq (protein)	NP_003384	n/a
Location (UCSC)	Chr 10: 100.46 – 100.48 Mb	Chr 19: 44.49 – 44.51 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

This gene is a member of the WNT gene family. It encodes a protein showing 95%, 86%, and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000075290 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036961 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lako M, Strachan T, Curtis AR, Lindsay S (Sep 1996). "Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24". Genomics. 35 (2): 386–8. doi:10.1006/geno.1996.0374. PMID 8661156.
6. "Entrez Gene: WNT8B wingless-type MMTV integration site family, member 8B".

Further reading

• Katoh M, Katoh M (2007). "Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs". Int. J. Oncol. 30 (5): 1273–7. doi:10.3892/ijo.30.5.1273. PMID 17390031.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Saitoh T, Mine T, Katoh M (2002). "Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells". Int. J. Oncol. 20 (5): 999–1003. doi:10.3892/ijo.20.5.999. PMID 11956596.
• Saitoh T, Mine T, Katoh M (2002). "Up-regulation of WNT8B mRNA in human gastric cancer". Int. J. Oncol. 20 (2): 343–8. doi:10.3892/ijo.20.2.343. PMID 11788899.
• Lako M, Lindsay S, Bullen P, et al. (1998). "A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain". Hum. Mol. Genet. 7 (5): 813–22. doi:10.1093/hmg/7.5.813. PMID 9536085.
• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.