Aceclidine

Aceclidine (Glaucostat, Glaunorm, Glaudin) is a parasympathomimetic miotic agent used in the treatment of narrow angle glaucoma. It decreases intraocular pressure.

Aceclidine

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical (ophthalmic solution)
ATC code	S01EB08 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolism	deacetylation?
Identifiers
IUPAC name 1-Azabicyclo[2.2.2]oct-3-yl acetate; 3-Quinuclidinyl Acetate
CAS Number	827-61-2 6109-70-2 (HCl)
PubChem CID	1979
ChemSpider	1902
UNII	0578K3ELIO
KEGG	D02750
ChEMBL	ChEMBL20835
CompTox Dashboard (EPA)	DTXSID2045658
ECHA InfoCard	100.011.431
Chemical and physical data
Formula	C9H15NO2
Molar mass	169.224 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C(OC2C1CCN(CC1)C2)C
InChI InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3 Key:WRJPSSPFHGNBMG-UHFFFAOYSA-N
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Adverse effects

Side effects of aceclidine include increased salivation and bradycardia (in excessive doses).

Mechanism of action

Aceclidine acts as a muscarinic acetylcholine receptor agonist.[1]

See also

• Talsaclidine (drug with a similar structure)
• Muscarine

References

1. Shannon HE, Hart JC, Bymaster FP, et al. (August 1999). "Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats". J. Pharmacol. Exp. Ther. 290 (2): 901–7. PMID 10411607.