CCRL2

C-C chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene.[5][6] Recently it was found that CCRL2 also acts as a receptor for the chemokine chemerin.[7]

CCRL2
Identifiers
Aliases	CCRL2, ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR, C-C motif chemokine receptor like 2
External IDs	OMIM: 608379 MGI: 1920904 HomoloGene: 2948 GeneCards: CCRL2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 46,407,166 bp[1] End 46,412,997 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F2|9 60.92 cM Start 111,054,486 bp[2] End 111,057,519 bp[2]
Gene ontology Molecular function • G-protein coupled receptor activity • chemokine receptor activity • signal transducer activity • CCR chemokine receptor binding • chemokine receptor binding • C-C chemokine receptor activity • chemokine binding • C-C chemokine binding Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane • cytoplasm • external side of plasma membrane Biological process • chemotaxis • G-protein coupled receptor signaling pathway • signal transduction • chemokine-mediated signaling pathway • inflammatory response • immune response • positive regulation of cytosolic calcium ion concentration • calcium-mediated signaling • cell chemotaxis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9034	54199
Ensembl	ENSG00000121797	ENSMUSG00000043953
UniProt	O00421	O35457
RefSeq (mRNA)	NM_001130910 NM_003965	NM_017466 NM_001302376 NM_001302377
RefSeq (protein)	NP_001124382 NP_003956	NP_001289305 NP_001289306 NP_059494
Location (UCSC)	Chr 3: 46.41 – 46.41 Mb	Chr 9: 111.05 – 111.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000121797 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043953 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fan P, Kyaw H, Su K, Zeng Z, Augustus M, Carter KC, Li Y (Mar 1998). "Cloning and characterization of a novel human chemokine receptor". Biochem Biophys Res Commun. 243 (1): 264–8. doi:10.1006/bbrc.1997.7981. PMID 9473515.
6. "Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2".
7. Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC (September 2008). "Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis". J. Exp. Med. 205 (10): 2207–20. doi:10.1084/jem.20080300. PMC 2556791. PMID 18794339.

External links

• Human CCRL2 genome location and CCRL2 gene details page in the UCSC Genome Browser.

Further reading

• Daugherty BL, Springer MS (1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21". Genomics. 41 (2): 294–5. doi:10.1006/geno.1997.4626. PMID 9143512.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Galligan CL, Matsuyama W, Matsukawa A, et al. (2004). "Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis". Arthritis Rheum. 50 (6): 1806–14. doi:10.1002/art.20275. PMID 15188357.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.