Interleukin 1 receptor, type I

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.[5]

IL1R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G0Y, 1IRA, 1ITB, 4DEP, 4GAF
Identifiers
Aliases	IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, Interleukin 1 receptor, type I, interleukin 1 receptor type 1
External IDs	OMIM: 147810 MGI: 96545 HomoloGene: 677 GeneCards: IL1R1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2-q12.1 Start 102,064,544 bp[1] End 102,179,874 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 B|1 18.81 cM Start 40,225,080 bp[2] End 40,317,257 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • interleukin-1, Type I, activating receptor activity • signal transducer activity • platelet-derived growth factor receptor binding • protease binding • GO:0001948 protein binding • transmembrane signaling receptor activity • interleukin-1 receptor activity • interleukin-1 binding Cellular component • integral component of membrane • membrane • cell membrane • integral component of plasma membrane • extracellular region • cell surface • external side of plasma membrane Biological process • cell surface receptor signaling pathway • immune response • regulation of inflammatory response • signal transduction • positive regulation of interleukin-1-mediated signaling pathway • positive regulation of neutrophil extravasation • response to interleukin-1 • cytokine-mediated signaling pathway • interleukin-1-mediated signaling pathway • positive regulation of interferon-gamma production • positive regulation of T-helper 1 cell cytokine production • inflammatory response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3554	16177
Ensembl	ENSG00000115594	ENSMUSG00000026072
UniProt	P14778	P13504
RefSeq (mRNA)	NM_000877 NM_001288706 NM_001320978 NM_001320980 NM_001320981 NM_001320982 NM_001320983 NM_001320984 NM_001320985 NM_001320986	NM_001123382 NM_008362
RefSeq (protein)	NP_000868 NP_001275635 NP_001307907 NP_001307909 NP_001307910 NP_001307911 NP_001307912 NP_001307913 NP_001307914 NP_001307915	NP_001116854 NP_032388
Location (UCSC)	Chr 2: 102.06 – 102.18 Mb	Chr 1: 40.23 – 40.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.[5]

Interactions

Interleukin 1 receptor, type I has been shown to interact with PIK3R1,[6] Myd88[7][8] and IL1RAP.[9]

See also

• Cluster of differentiation
• Interleukin 1 receptor, type II

References

1. GRCh38: Ensembl release 89: ENSG00000115594 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026072 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IL1R1 interleukin 1 receptor, type I".
6. Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. UNITED STATES. 272 (46): 29167–73. doi:10.1074/jbc.272.46.29167. ISSN 0021-9258. PMID 9360994.
7. Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. ENGLAND. 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. S2CID 32036101.
8. Muzio, M; Ni J; Feng P; Dixit V M (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. UNITED STATES. 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458.
9. Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (24): 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

Further reading

• Copeland NG, Silan CM, Kingsley DM, et al. (1991). "Chromosomal location of murine and human IL-1 receptor genes". Genomics. 9 (1): 44–50. doi:10.1016/0888-7543(91)90219-5. PMID 1672292.
• McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". EMBO J. 10 (10): 2821–32. doi:10.1002/j.1460-2075.1991.tb07831.x. PMC 452992. PMID 1833184.
• Uhl J, Newton RC, Giri JG, et al. (1989). "Identification of IL-1 receptors on human monocytes". J. Immunol. 142 (5): 1576–81. PMID 2521881.
• Sims JE, Acres RB, Grubin CE, et al. (1989). "Cloning the interleukin 1 receptor from human T cells". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8946–50. Bibcode:1989PNAS...86.8946S. doi:10.1073/pnas.86.22.8946. PMC 298407. PMID 2530587.
• Chua AO, Gubler U (1990). "Sequence of the cDNA for the human fibroblast type interleukin-1 receptor". Nucleic Acids Res. 17 (23): 10114. doi:10.1093/nar/17.23.10114. PMC 335251. PMID 2532321.
• Dower SK, Kronheim SR, Hopp TP, et al. (1987). "The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical". Nature. 324 (6094): 266–8. Bibcode:1986Natur.324..266D. doi:10.1038/324266a0. PMID 2946959. S2CID 4233242.
• Rautonen N, Rautonen J, Martin NL, Wara DW (1995). "HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells". AIDS. 8 (10): 1504–6. doi:10.1097/00002030-199410000-00023. PMID 7818827.
• Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta". Nature. 386 (6621): 190–4. Bibcode:1997Natur.386..190V. doi:10.1038/386190a0. PMID 9062193. S2CID 4358379.
• Schreuder H, Tardif C, Trump-Kallmeyer S, et al. (1997). "A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist". Nature. 386 (6621): 194–200. Bibcode:1997Natur.386..194S. doi:10.1038/386194a0. PMID 9062194. S2CID 4266953.
• Rameshwar P, Poddar A, Zhu G, Gascón P (1997). "Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts". J. Immunol. 158 (7): 3417–24. PMID 9120302.
• Reddy SA, Huang JH, Liao WS (1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. 272 (46): 29167–73. doi:10.1074/jbc.272.46.29167. PMID 9360994.
• Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. PMC 24223. PMID 9371760.
• Muzio M, Ni J, Feng P, Dixit VM (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. PMID 9374458.
• Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
• Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit". Mol. Cell. Biol. 19 (7): 4798–805. doi:10.1128/mcb.19.7.4798. PMC 84278. PMID 10373529.
• Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325. S2CID 32036101.
• Vigers GP, Dripps DJ, Edwards CK, Brandhuber BJ (2001). "X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1". J. Biol. Chem. 275 (47): 36927–33. doi:10.1074/jbc.M006071200. PMID 10903327.
• Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614.
• Joos L, McIntyre L, Ruan J, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers". Thorax. 56 (11): 863–6. doi:10.1136/thorax.56.11.863. PMC 1745962. PMID 11641511.
• Köller M, Kutscha-Lissberg F, Brom J, et al. (2003). "Influence of low molecular weight heparin (certoparin) and unfractionated heparin on the release of cytokines from human leukocytes". Inflammation. 25 (5): 331–7. doi:10.1023/A:1012883916991. PMID 11820460. S2CID 21831719.

External links

• IL1R1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.