IFNAR2

Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.[5]

IFNAR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N6U, 1N6V, 2HYM, 2KZ1, 2LAG, 3S8W, 3S9D, 3SE3, 3SE4
Identifiers
Aliases	IFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha and beta receptor subunit 2
External IDs	OMIM: 602376 MGI: 1098243 HomoloGene: 49242 GeneCards: IFNAR2
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.11 Start 33,229,901 bp[1] End 33,265,675 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C3.3|16 52.82 cM Start 91,372,783 bp[2] End 91,405,589 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • type I interferon binding • protein kinase binding • type I interferon receptor activity • cytokine receptor activity Cellular component • integral component of membrane • extracellular region • cell membrane • integral component of plasma membrane • membrane • intracellular • extracellular Biological process • cell surface receptor signaling pathway • response to virus • JAK-STAT cascade • regulation of type I interferon-mediated signaling pathway • type I interferon signaling pathway • response to interferon-alpha • response to interferon-beta • defense response to virus • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3455	15976
Ensembl	ENSG00000159110	ENSMUSG00000022971
UniProt	P48551	O35664
RefSeq (mRNA)	NM_207585 NM_000874 NM_001289125 NM_001289126 NM_001289128 NM_207584	NM_001110498 NM_010509 NM_001347258
RefSeq (protein)	NP_000865 NP_001276054 NP_001276055 NP_001276057 NP_997467 NP_997468	NP_001103968 NP_001334187 NP_034639
Location (UCSC)	Chr 21: 33.23 – 33.27 Mb	Chr 16: 91.37 – 91.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.[6]

Interactions

IFNAR2 has been shown to interact with:

• GNB2L1,[7][8]
• IFNA2,[9]
• STAT1,[7][10] and
• STAT2.[10][11]

References

1. GRCh38: Ensembl release 89: ENSG00000159110 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022971 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Novick D, Cohen B, Rubinstein M (June 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell. 77 (3): 391–400. doi:10.1016/0092-8674(94)90154-6. PMID 8181059. S2CID 140206806.
6. "Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2".
7. Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (June 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. 276 (25): 22948–53. doi:10.1074/jbc.M100087200. PMID 11301323.
8. Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (November 2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. 165 (9): 5127–32. doi:10.4049/jimmunol.165.9.5127. PMID 11046044.
9. Piehler J, Schreiber G (May 1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol. 289 (1): 57–67. doi:10.1006/jmbi.1999.2726. PMID 10339405.
10. Li X, Leung S, Kerr IM, Stark GR (April 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052. PMID 9121453.
11. Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (March 2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem. 277 (12): 9713–21. doi:10.1074/jbc.M111161200. PMID 11786546.

Further reading

• Caraglia M, Marra M, Pelaia G, Maselli R, Caputi M, Marsico SA, Abbruzzese A (2005). "Alpha-interferon and its effects on signal transduction pathways". J. Cell. Physiol. 202 (2): 323–35. doi:10.1002/jcp.20137. PMID 15389589. S2CID 4833543.
• Raz R, Cheung K, Ling L, Levy DE (1995). "Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness". Somat. Cell Mol. Genet. 21 (2): 139–45. doi:10.1007/BF02255789. PMID 7570186. S2CID 972314.
• Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE (1995). "Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster". EMBO J. 14 (20): 5100–8. doi:10.1002/j.1460-2075.1995.tb00192.x. PMC 394613. PMID 7588638.
• Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR (1995). "Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling". J. Biol. Chem. 270 (37): 21606–11. doi:10.1074/jbc.270.37.21606. PMID 7665574.
• Novick D, Cohen B, Tal N, Rubinstein M (1995). "Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor". J. Leukoc. Biol. 57 (5): 712–8. doi:10.1002/jlb.57.5.712. PMID 7759950.
• Platanias LC, Uddin S, Domanski P, Colamonici OR (1996). "Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor". J. Biol. Chem. 271 (39): 23630–3. doi:10.1074/jbc.271.39.23630. PMID 8798579.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Croze E, Russell-Harde D, Wagner TC, Pu H, Pfeffer LM, Perez HD (1996). "The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein". J. Biol. Chem. 271 (52): 33165–8. doi:10.1074/jbc.271.52.33165. PMID 8969169.
• Li X, Leung S, Kerr IM, Stark GR (1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052. PMID 9121453.
• Piehler J, Schreiber G (1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol. 289 (1): 57–67. doi:10.1006/jmbi.1999.2726. PMID 10339405.
• Chuntharapai A, Gibbs V, Lu J, Ow A, Marsters S, Ashkenazi A, De Vos A, Jin Kim K (1999). "Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2". J. Immunol. 163 (2): 766–73. PMID 10395669.
• Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. 165 (9): 5127–32. doi:10.4049/jimmunol.165.9.5127. PMID 11046044.
• Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. 276 (25): 22948–53. doi:10.1074/jbc.M100087200. PMID 11301323.
• Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem. 277 (12): 9713–21. doi:10.1074/jbc.M111161200. PMID 11786546.
• Chill JH, Nivasch R, Levy R, Albeck S, Schreiber G, Anglister J (2002). "The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening". Biochemistry. 41 (11): 3575–85. doi:10.1021/bi011778f. PMID 11888273.
• Velichko S, Wagner TC, Turkson J, Jove R, Croze E (2002). "STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues". J. Biol. Chem. 277 (38): 35635–41. doi:10.1074/jbc.M204578200. PMID 12105218.
• Usacheva A, Kotenko S, Witte MM, Colamonici OR (2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. 169 (3): 1302–8. doi:10.4049/jimmunol.169.3.1302. PMID 12133952.
• Gauzzi MC, Canini I, Eid P, Belardelli F, Gessani S (2002). "Loss of type I IFN receptors and impaired IFN responsiveness during terminal maturation of monocyte-derived human dendritic cells". J. Immunol. 169 (6): 3038–45. doi:10.4049/jimmunol.169.6.3038. PMID 12218119.