Diosmetin

Diosmetin, also known as 5,7,3'-trihydroxy-4'-methoxyflavone, is an O-methylated flavone, a chemical compound that can be found in the Caucasian vetch.[1]

Diosmetin

Names
IUPAC name 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
Other names Luteolin 4'-methyl ether 3′,5,7-trihydroxy-4′-methoxyflavone
Identifiers
CAS Number	520-34-3
3D model (JSmol)	Interactive image
ChEBI	CHEBI:4630
ChEMBL	ChEMBL90568
ChemSpider	4444931
ECHA InfoCard	100.007.539
PubChem CID	5281612
UNII	TWZ37241OT
CompTox Dashboard (EPA)	DTXSID80199966
InChI InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3 Key: MBNGWHIJMBWFHU-UHFFFAOYSA-N InChI=1/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3 Key: MBNGWHIJMBWFHU-UHFFFAOYAU
SMILES COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
Properties
Chemical formula	C16H12O6
Molar mass	300.26 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

It has been found to act as a weak TrkB receptor agonist.[2]

Glycosides

Diosmetin is the aglycone of diosmin.

See also

• Tropomyosin receptor kinase B § Agonists

References

1. Diosmetin glycosides from caucasian vetch: Isolation and study of biological activity
   O. A. Andreeva, M. N. Ivashev, I. I. Ozimina and G. V. Maslikova, 1994
2. Jang SW, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y, Wilson WD, Xiao G, Blanchi B, Sun YE, Ye K (2010). "A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone". Proc. Natl. Acad. Sci. U.S.A. 107 (6): 2687–92. doi:10.1073/pnas.0913572107. PMC 2823863. PMID 20133810.