EPHA10

EPH receptor A10 is a protein in humans that is encoded by the EPHA10 gene.[5]

EPHA10
Identifiers
Aliases	EPHA10, EPH receptor A10
External IDs	OMIM: 611123 MGI: 3586824 HomoloGene: 67804 GeneCards: EPHA10
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 37,713,880 bp[1] End 37,765,133 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 124,880,899 bp[2] End 124,917,800 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • transmembrane-ephrin receptor activity • kinase activity • GO:0001948 protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • ephrin receptor activity • receptor tyrosine kinase • transmembrane signaling receptor activity Cellular component • integral component of membrane • membrane • cell membrane • integral component of plasma membrane • extracellular region • cytoplasm • neuron projection • receptor complex Biological process • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • protein phosphorylation • peptidyl-tyrosine phosphorylation • ephrin receptor signaling pathway • biological process • negative regulation of signal transduction • cell differentiation • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	284656	230735
Ensembl	ENSG00000183317	ENSMUSG00000028876
UniProt	Q5JZY3	Q8BYG9
RefSeq (mRNA)	NM_001004338 NM_001099439 NM_173641	NM_001256432 NM_177671
RefSeq (protein)	NP_001092909 NP_775912	NP_001243361 NP_808339
Location (UCSC)	Chr 1: 37.71 – 37.77 Mb	Chr 4: 124.88 – 124.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells.[5] See MIM 179610 for additional background on Eph receptors and ephrins.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000183317 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028876 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Aasheim HC, Patzke S, Hjorthaug HS, Finne EF (May 2005). "Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis". Biochimica et Biophysica Acta (BBA) - General Subjects. 1723 (1–3): 1–7. doi:10.1016/j.bbagen.2005.01.011. PMID 15777695.
6. "MIM 179610". Online Mendelian Inheritance in Man. January 5, 2010. Retrieved August 6, 2013.

Further reading