Encainide

Encainide (trade name Enkaid) is a class Ic antiarrhythmic agent. It is no longer used because of its frequent proarrhythmic side effects.[1]

Encainide

Clinical data
Trade names	Enkaid
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a605040
ATC code	C01BC08 (WHO)
Legal status
Legal status	Withdrawn
Identifiers
IUPAC name 4-Methoxy-N-[2-(1-methyl-2-piperidin-1-ylethyl)phenyl]benzamide
CAS Number	66778-36-7
PubChem CID	48041
DrugBank	DB01228
ChemSpider	43697
UNII	SY3J0147NB
KEGG	D07894
ChEBI	CHEBI:4788
ChEMBL	ChEMBL315838
CompTox Dashboard (EPA)	DTXSID0022983
Chemical and physical data
Formula	C22H28N2O2
Molar mass	352.478 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC
InChI InChI=1S/C22H28N2O2/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25) Key:PJWPNDMDCLXCOM-UHFFFAOYSA-N
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Synthesis

Encainide synthesis:[2][3][4]

See also

• Cardiac Arrhythmia Suppression Trial

References

1. Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, et al. (March 1991). "Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial". The New England Journal of Medicine. 324 (12): 781–8. doi:10.1056/NEJM199103213241201. PMID 1900101.
2. DE 2210154, Dykstra SJ, Minelli JL, issued 1972
3. US 3931195, Dykstra SJ, Minelli JL, issued 1976
4. Dykstra SJ, Minielli JL, Lawson JE, Ferguson HC, Dungan KW (September 1973). "Lysergic acid and quinidine analogs. 2-(o-Acylaminophenethyl)piperidines". Journal of Medicinal Chemistry. 16 (9): 1015–20. doi:10.1021/jm00267a012. PMID 4745503.