Endothelin 1

Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor that in humans is encoded by the EDN1 gene and produced by vascular endothelial cells. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. Endothelin 1 is one of three isoforms of human endothelin.

EDN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEDN1, ARCND3, ET1, HDLCQ7, QME, endothelin 1, PPET1
External IDsMGI: 95283 HomoloGene: 1476 GeneCards: EDN1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p24.1Start12,290,361 bp[1]
End12,297,194 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1906

13614

Ensembl

ENSG00000078401

ENSMUSG00000021367

UniProt

P05305

P22387

RefSeq (mRNA)

NM_001168319
NM_001955

NM_010104

RefSeq (protein)

NP_001161791
NP_001946
NP_001161791
NP_001946

NP_034234

Location (UCSC)Chr 6: 12.29 – 12.3 MbChr 13: 42.3 – 42.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Source

Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.[5]

Clinical significance

Long term ET-1 exposure has been associated with hypertrophic cardiomyopathy.[6]

Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.

References

  1. GRCh38: Ensembl release 89: ENSG00000078401 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021367 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 978-1-4160-3115-4.
  6. Archer CR, Robinson EL, Drawnel FM, Roderick HL (August 2017). "Endothelin-1 promotes hypertrophic remodelling of cardiac myocytes by activating sustained signalling and transcription downstream of endothelin type A receptors". Cellular Signalling. 36: 240–254. doi:10.1016/j.cellsig.2017.04.010. PMC 5486433. PMID 28412414.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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