mir-589 microRNA precursor family
In molecular biology mir-589 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-589 | |
|---|---|
| Identifiers | |
| Symbol | mir-589 |
| Rfam | RF00987 |
| miRBase family | MIPF0000496 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Molecular targets
miR-589 has been implicated in the regulation of antimicrobial targets in bovine lung alveolar macrophages, and alongside other miRNAs has been suggested to play a part in the immune response against Mycobacterium tuberculosis.[1] It has additionally been linked to HLA-G expression, having been found to target the 3'UTR 14-base pair sequence region of the HLA-G gene.[2]
See also
References
- Xu G, Zhang Y, Jia H, Li J, Liu X, Engelhardt JG, et al. (2009). "Cloning and identification of microRNAs in bovine alveolar macrophages". Mol Cell Biochem. 332 (1–2): 9–16. doi:10.1007/s11010-009-0168-4. PMID 19507003.
- Castelli EC, Moreau P, Oya e Chiromatzo A, Mendes-Junior CT, Veiga-Castelli LC, Yaghi L, et al. (2009). "In silico analysis of microRNAS targeting the HLA-G 3' untranslated region alleles and haplotypes". Hum Immunol. 70 (12): 1020–5. doi:10.1016/j.humimm.2009.07.028. PMID 19664672.
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