mir-765 microRNA precursor family

In molecular biology mir-765 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-765
Identifiers
Symbolmir-765
RfamRF01027
miRBase familyMIPF0000545
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

Traumatic Brain Injury

miR-765 has been identified as a diagnostic marker for traumatic brain injury (TBI), due to significantly elevated levels in the plasma of TBI patients. Furthermore, combination with either miR-16 or miR-92a allows extremely accurate distinction between TBI patients and healthy controls.[1]

miR-765 and pheochromocytomas

Increased miR-765 expression is observed in Von Hippel-Lindau disease compared with the sporadic benign forms of pheochromocytomas.[2] It has been linked to neuronal plasticity through the neurotrophic tyrosine kinase receptor type 3 (NTRK3) gene. A NTRK3 3'UTR variant, ss102661458, is located in a functional target site of miR-765 and is able to significantly affect miRNA-mediated NTRK3 regulation. Through this there is restoration of the altered gene expression by miR-765. NTRK3 is underexpressed with high or overexpressed levels of miR-765, thus pointing towards a possible involvement of this relationship in pheochromocytoma pathogenesis.[3]

See also

References
  1. Redell JB, Moore AN, Ward NH, Hergenroeder GW, Dash PK (2010). "Human traumatic brain injury alters plasma microRNA levels". J. Neurotrauma. 27 (12): 2147–56. doi:10.1089/neu.2010.1481. PMC 6468948. PMID 20883153.
  2. Tömböl Z, Eder K, Kovács A, Szabó PM, Kulka J, Likó I, et al. (2010). "MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomas". Mod. Pathol. 23 (12): 1583–95. doi:10.1038/modpathol.2010.164. PMID 20818339.
  3. Muiños-Gimeno M, Guidi M, Kagerbauer B, Martín-Santos R, Navinés R, Alonso P, et al. (2009). "Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders". Hum. Mutat. 30 (7): 1062–71. doi:10.1002/humu.21005. hdl:10230/16310. PMID 19370765.

Further reading

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