mir-764 microRNA precursor family
In molecular biology mir-764 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-764 | |
|---|---|
| Identifiers | |
| Symbol | mir-764 |
| Rfam | RF01920 |
| miRBase family | MIPF0000707 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Osteoblast Differentiation
Expression of the mature miR-764-5p sequence is upregulated during osteoblast differentiation in both skull-specific calvarial and osteoblast progenitor cells. The channel-forming integral protein, CHIP, is regulated by miR-764-5p at its 3'UTR, and there is negative correlation between expression of the two. Increased CHIP levels are observed with inhibition of miR-764-5p, whilst enhanced miR-764-3p expression sees decreased CHIP levels.[1] The differentiation fate of osteoblast progenitor cells is altered by impaired miR-764-3p levels due to CHIP. Osteoblast differentiation from progenitor cells has been shown to be positively regulated by repressed CHIP translation.
See also
References
- Guo J, Ren F, Wang Y, Li S, Gao Z, Wang X, et al. (2012). "miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression". J Bone Miner Res. 27 (7): 1607–18. doi:10.1002/jbmr.1597. PMID 22407479.