Neurocalcin

Neurocalcin is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins.[1][2] It expressed in mammalian brains. It possesses a Ca2+/myristoyl switch

neurocalcin delta
Identifiers
SymbolNCALD
NCBI gene83988
HGNC7655
OMIM606722
RefSeqNM_001040628
UniProtP61601
Other data
LocusChr. 8 q22-q23

The subclass of neurocalcins are brain-specific proteins that fit into the EF-hand superfamily of calcium binding proteins. The NCS family were defined by the photoreceptor cell-specific protein, recoverin. Neurocalcin was purified from the bovine brain by using calcium-dependent drug affinity chromatography. The amino acid sequence showed that neurocalcin has three functional calcium binding sites. It is expressed in the central nervous system, retina, and adrenal gland. With this unique pattern of expression it is thought that neurcalcin offers a different physiological role than similar proteins visinin and recoverin.

Neurocalcin delta an isoform of Neurocalcin is known to regulate adult neurogenesis ( Upadhyay et al., 2019)

References
  1. Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
  2. Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879. S2CID 24156457.


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