RAMP1

Receptor activity modifying protein 1 is a protein that in humans is encoded by the RAMP1 gene.[5][6]

RAMP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YX8, 3N7P, 3N7R, 3N7S, 4RWG
Identifiers
Aliases	RAMP1, entrez:10267, receptor activity modifying protein 1
External IDs	OMIM: 605153 MGI: 1858418 HomoloGene: 4275 GeneCards: RAMP1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 237,858,893 bp[1] End 237,912,106 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 D|1 46.08 cM Start 91,179,822 bp[2] End 91,225,196 bp[2]
Gene ontology Molecular function • coreceptor activity • calcitonin receptor activity • calcitonin receptor binding • GO:0001948 protein binding • calcitonin gene-related peptide receptor activity • amylin receptor activity • calcitonin gene-related peptide binding Cellular component • integral component of membrane • membrane • cell membrane • receptor complex • integral component of plasma membrane • intracellular • cell surface • extracellular • amylin receptor complex 1 • CGRP receptor complex Biological process • G-protein coupled receptor signaling pathway • positive regulation of protein glycosylation • regulation of G-protein coupled receptor protein signaling pathway • receptor internalization • angiogenesis • transport • protein transport • protein localization to plasma membrane • intracellular protein transport • calcium ion transport • adenylate cyclase-activating G-protein coupled receptor signaling pathway • cellular response to hormone stimulus • amylin receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10267	51801
Ensembl	ENSG00000132329	ENSMUSG00000034353
UniProt	O60894	Q9WTJ5
RefSeq (mRNA)	NM_001308353 NM_005855	NM_001168392 NM_016894 NM_178401
RefSeq (protein)	NP_001295282 NP_005846	NP_001161864 NP_058590 NP_848488
Location (UCSC)	Chr 2: 237.86 – 237.91 Mb	Chr 1: 91.18 – 91.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CALCRL) to the plasma membrane. CALCRL, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In combination with the RAMP1 protein, CALCRL functions as the CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.[5] The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts CT from a calcitonin receptor to the amylin receptor AMY₁ [7]

See also

• Receptor activity-modifying protein

References

1. GRCh38: Ensembl release 89: ENSG00000132329 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034353 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RAMP1".
6. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–9. doi:10.1038/30666. PMID 9620797. S2CID 4364526.
7. • "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Kusano S, Kukimoto-Niino M, Akasaka R, et al. (2008). "Crystal structure of the human receptor activity-modifying protein 1 extracellular domain". Protein Sci. 17 (11): 1907–14. doi:10.1110/ps.036012.108. PMC 2578806. PMID 18725456.
• Héroux M, Hogue M, Lemieux S, Bouvier M (2007). "Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1". J. Biol. Chem. 282 (43): 31610–20. doi:10.1074/jbc.M701790200. PMID 17785463.
• Kuwasako K, Cao YN, Nagoshi Y, et al. (2004). "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins". Mol. Pharmacol. 65 (1): 207–13. doi:10.1124/mol.65.1.207. PMID 14722252.
• Nagoshi Y, Kuwasako K, Cao YN, et al. (2004). "Tumor necrosis factor-alpha downregulates adrenomedullin receptors in human coronary artery smooth muscle cells". Peptides. 25 (7): 1115–21. doi:10.1016/j.peptides.2004.04.010. PMID 15245870. S2CID 54255777.
• Kuwasako K, Kitamura K, Nagoshi Y, Eto T (2003). "Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins". Biochem. Biophys. Res. Commun. 301 (2): 460–4. doi:10.1016/S0006-291X(02)03072-3. PMID 12565884.
• Wang YF, Zhang J, Li J, et al. (2004). "[Increased atria expression of receptor activity-modifying proteins in heart failure patients]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 21 (4): 351–4. PMID 15300632.
• Eskesen K, János T, Tibor H, et al. (2007). "Unaltered mRNA expression of calcitonin-like receptor and receptor activity modifying proteins in human arteries in stroke and myocardial infarction". Ideggyogy Sz. 60 (11–12): 459–66. PMID 18198792.
• Foord SM, Marshall FH (1999). "RAMPs: accessory proteins for seven transmembrane domain receptors". Trends Pharmacol. Sci. 20 (5): 184–7. doi:10.1016/S0165-6147(99)01347-4. PMID 10354609.
• Fitzsimmons TJ, Zhao X, Wank SA (2003). "The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function". J. Biol. Chem. 278 (16): 14313–20. doi:10.1074/jbc.M211946200. PMID 12574158.
• Kuwasako K, Kitamura K, Nagoshi Y, et al. (2003). "Identification of the human receptor activity-modifying protein 1 domains responsible for agonist binding specificity". J. Biol. Chem. 278 (25): 22623–30. doi:10.1074/jbc.M302571200. PMID 12684503.
• Bomberger JM, Parameswaran N, Hall CS, et al. (2005). "Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking". J. Biol. Chem. 280 (10): 9297–307. doi:10.1074/jbc.M413786200. PMID 15613468.
• Nakazato T, Nakayama T, Naganuma T, et al. (2009). "Haplotype-based case-control study of receptor (calcitonin) activity-modifying protein-1 gene in cerebral infarction". J Hum Hypertens. 24 (5): 351–358. doi:10.1038/jhh.2009.68. PMID 19710695.
• Cottrell GS, Padilla B, Pikios S, et al. (2007). "Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1". J. Biol. Chem. 282 (16): 12260–71. doi:10.1074/jbc.M606338200. PMID 17310067.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kunz TH, Mueller-Steiner S, Schwerdtfeger K, et al. (2007). "Interaction of receptor-activity-modifying protein1 with tubulin". Biochim. Biophys. Acta. 1770 (8): 1145–50. doi:10.1016/j.bbagen.2007.04.002. PMID 17493758.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Udawela M, Christopoulos G, Morfis M, et al. (2006). "A critical role for the short intracellular C terminus in receptor activity-modifying protein function". Mol. Pharmacol. 70 (5): 1750–60. doi:10.1124/mol.106.024257. PMID 16912219. S2CID 7249716.
• Padilla BE, Cottrell GS, Roosterman D, et al. (2007). "Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins". J. Cell Biol. 179 (5): 981–97. doi:10.1083/jcb.200704053. PMC 2099187. PMID 18039931.
• Russo AF (2007). "Ramping it up: RAMP1 and the implications for migraine". Pharmacogenomics. 8 (7): 687–90. doi:10.2217/14622416.8.7.687. PMID 18240900.
• Qi T, Christopoulos G, Bailey RJ, et al. (2008). "Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function". Mol. Pharmacol. 74 (4): 1059–71. doi:10.1124/mol.108.047142. PMID 18593822. S2CID 33491956.

External links

• "Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• RAMP1 human gene location in the UCSC Genome Browser.
• RAMP1 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.